Comment · Sat, November 24, 2012
MDMA Neurotoxicity Part 1 Metabolites)
Original post in this thread
MisterYouAreSoDumb · 129 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
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First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
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MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
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slyman928 · 1 points
no just a place with a stage and whatnot. but yea do you take them in with their containers or as loose tablets and capsules? i don't think i'd want to go through that much trouble and they have the choice not to let you in regardless, getting the police involved would only help if like they're going to reagent test them to prove there's nothing on/in them and who knows if they'd even do that.
u/MisterYouAreSoDumb
Loose tablets usually. I keep the different ones in different pockets. Most of the time I only bring in magnesium glycinate tablets, Alpha lipoic acid capsules, Emercen-C packets, and maybe an EGCG capsule.
Usually if you readily involve the police in a discussion, they believe you that they are just vitamins. No sane person would knowingly call the police over and show them illegal drugs.