Comment · Thu, December 20, 2012
MDMA Neurotoxicity Part 1 Metabolites)
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MisterYouAreSoDumb · 129 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
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First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
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MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
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Monkey_in_a_Barrel · 1 points
Holy shit dude, that's the most awesome and informed guide I've ever seen. Mad thanks to you, you are going to be single-handedly (don't tell my dealer I said this) responsible for the best and safest new years I've ever had.
One thing, I'm probably gonna add a fat doob in there somewhere ;) Or if I'm incredibly lucky, some 2C-B on the comedown. Actually, on that subject, what are your thoughts on 2C-B?
u/MisterYouAreSoDumb
Definitely THC. I protects for neurotoxicity and potentiates the roll.
I've never done 2C-B, so I cannot comment on it's use on the comedown. I would try to keep the dosages low if you decide on it.