Comment · Thu, November 29, 2012
Magnesium L-Threonate's MoA
Original post in this thread
Arkanj3l · 3 points
Jonathan Toomim dropped this tight rap about MLT and how it potentially worked as a cognitive enhancer. It might not have anything to do with L-Threonate per se and just the bioavailability; one may expect similar effects from less bioavailable substances dosed en masse?
(Taking out some linear programming chart or something would figure out if supping with MLT versus some other type of mag would be more effective. Anyway, enjoy.)
>Yes, it still seems high. Magnesium L-threonate has a molecular weight
of 284.5, of which 24.3 is Mg, so it's only 560 mg of elemental
magnesium. Still, that sounds like a lot, especially since it's
supposed to have higher bioavailability than other forms of Mg. The
NIH recommended maximum for Mg is 350 mg/day (http://en.wikipedia.org/wiki/Magnesium_citrate#Dosage
).
I'm curious whether the innovation in the Slutsky et al study was just
the high dosage (combined with the higher bioavailability), rather
than the use of the L-threonate salt itself. I couldn't find a mention
of the dosage they used with the magnesium citrate and
I took a look through the Slutsky e…
What they were answering
silverhydra · 1 points
Apparently not, although citation 99 hints at it:
will only increase CSF magnesium concentrations to a very limited degree (approximately 11-18 per cent)
So I guess my 11% from memory was the lower end of things; whoops.
u/MisterYouAreSoDumb
I'm not seeing that in the abstract.
I am not seeing it anywhere in there. Could you be looking at different study?