Comment · Thu, November 29, 2012
Magnesium L-Threonate's MoA
Original post in this thread
Arkanj3l · 3 points
Jonathan Toomim dropped this tight rap about MLT and how it potentially worked as a cognitive enhancer. It might not have anything to do with L-Threonate per se and just the bioavailability; one may expect similar effects from less bioavailable substances dosed en masse?
(Taking out some linear programming chart or something would figure out if supping with MLT versus some other type of mag would be more effective. Anyway, enjoy.)
>Yes, it still seems high. Magnesium L-threonate has a molecular weight
of 284.5, of which 24.3 is Mg, so it's only 560 mg of elemental
magnesium. Still, that sounds like a lot, especially since it's
supposed to have higher bioavailability than other forms of Mg. The
NIH recommended maximum for Mg is 350 mg/day (http://en.wikipedia.org/wiki/Magnesium_citrate#Dosage
).
I'm curious whether the innovation in the Slutsky et al study was just
the high dosage (combined with the higher bioavailability), rather
than the use of the L-threonate salt itself. I couldn't find a mention
of the dosage they used with the magnesium citrate and
I took a look through the Slutsky e…
What they were answering
Arkanj3l · 1 points
I like this approach of saturating a neuron's potential binding sites. Can that be copied to different receptor-types? Granted, NDMA-excitability lets modulates the firing of local synapses, so maybe it's not worth doing except for NDMARs. Hmm.
u/MisterYouAreSoDumb
Sure, that's what aniracetam does at the AMPA receptors. Piracetam also has unique AMPA binding sites as well.