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Procter & Gamble will acquire supplements brand Thorne for $3.8 billion, CEO tells CNBC

Replying to Simple_Song8962 · How in the hell did it go up by $3 Billion in just 3 years?

This is what private equity does. They buy up companies with trusted names, come in and cut a bunch of the shit that made the companies trusted in the first place, which lowers overhead costs. They then do big marketing pushes to increase short term demand, pushing EBITDA up, due…

Procter & Gamble will acquire supplements brand Thorne for $3.8 billion, CEO tells CNBC

Replying to aTrueBraj · Noooooooooooooo

I mean, it has been owned by L Catterton, the investment arm of Luis Vuitton Moet Hennessy, for 3 years. They fired their whole scientific team 2.5 years ago. We knew a guy that worked on their scientific team for 15 years that was cut when the new ownership came in. Thorne's fat…

How do you actually shop for third-party tested supplements without falling for a badge?

Replying to lionsbrain · HPTLC is a common and even standard way to identify saffron, but it mostly reflects chemical profiles rather than species-level identity. Closely related species could produce a si…

We do DNA analysis as well, though LeafWorks. However, that only tells you species level confirmation. You don't get plant part or metabolomic profiling that you get with HPTLC, or with a novel NMR technique like PurityIQ is using... which we also work with! It's nice to get DNA…

How do you actually shop for third-party tested supplements without falling for a badge?

Replying to 10MileHike · *This is just another contract manufacturer!!*! Yeah ...."the formulator told us what recipe they used, so it must be in there!"

This is happening a LOT lately. As consumers start to demand COAs more, brands are putting them on the sites more. However, many times those are just supplier COAs. These contract manufacturers are getting better at making them look legit as well, confusing consumers. Then even I…

How do you actually shop for third-party tested supplements without falling for a badge?

/u/Pretty-Chill talked some about what you should look for in a positive way. I will talk about what you should look out for as red flags. Let's take a brand that has been blowing up lately, because they got David Beckham to come on to shill it: IM-8. I will link one of their Ins…

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to Warren_sl · I don’t know if they’re using CellG8 anymore they removed all references to them. I think the gel was always a different manufacturer but I’m unsure who. Maybe EffePharm?

Could be. I'd have to get another sample from them and test again. Whatever it was a year and a half ago was not a liposome. I've been pretty vocal about calling that out, so maybe people have finally switched suppliers to a real one. I didn't end up buying the Nanosight. We just…

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to Warren_sl · Please offer the liposomal NMN/NR as a lozenge or powder. The lipo NMN gel from Renue by science gives the most sustained and fast rush of every I’ve had from any NAD product secon…

I believe Renue was using CellG8 as the supplier, which we tested in the lab using the Malvern Nanosight system. We found not only was it not a liposome, it wouldn't even get into solution to properly inject into the machine. We dissolved what we could, which was like 1/4 of the…

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to Warren_sl · Haha. For what it’s worth I’ve taken up to 500mg of NMNH in a single dose and I didn’t think it was worth the cost over NMN taken orally. I wonder if it would be much better subli…

Yeah, that was my read as well. I am considering doing a liposomal NMN, as we did finally find someone making it for real, and doing proper cryoTEM and pharmacokinetic studies. My fight over liposomes wasn't that they were bullshit in theory. It's that nobody was even doing testi…

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to Warren_sl · You’d be the first NRH on market probably if you brought it out.

"If you ain't first, you're last!" -Ricky Bobby

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to JustAboutUpToSpeed · Any chance of NRH/NMNH from ND?

Potentially, but the costs are too high for now. We've been able to get both for many years, but the cost is insane. The increase in bioavailability/efficacy is real, but not if the cost is 10X.

Ashwagandha almost killed my liver – bilirubin hit 50 mg/dL, severe jaundice & itching for months. My warning story (21M)

Replying to MaintenanceOk7855 · Probably, for some ppl ash works better than any other nootropics. Companies like this make unsafe supplements probably this will push ppl to sway away from ash. Shoden was among …

Yes, the shitty supplement brands ruin the supplement market for everyone.

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to Fragrant-Corner7471 · Are you still taking NR?

Yes, along with NMN and NADH. I am taking our OptiNAD+ stack, which has them all in it, along with other supporting supplements, like CD38 inhibitors.

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

Replying to RarageInTheGarage · NMN is a fundamental biomolecule. Wasn't David Sinclair trying to get NR "regulated" as well, a while back?

That's correct. Tru Niagen patented nicotinamide riboside... which is a natural endogenous compound found in everyone's bodies and in multiple food sources. They tried to say they were the ones that "discovered" it, and that nobody else was allowed to sell it. For a while they su…

My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)

There is a lot of BS around the ND vs NMN stuff right now, and a ton of propaganda from Tru Niagen. In fact, they are trying to get NMN banned again. [Bioscience Company Sues FDA Over Dietary Supplement Reversal](https://news.bloomberglaw.com/health-law-and-business/tktk-7) They…

Ashwagandha almost killed my liver – bilirubin hit 50 mg/dL, severe jaundice & itching for months. My warning story (21M)

Replying to MaintenanceOk7855 · Was it a standardized one you took? Third party lab tested. I guess it's a fair warning for everyone. Hope you are well now and good luck.

FYI: [DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera \(Ashwagandha\)](https://doi.org/10.1016/j.crtox.2021.02.002)

Ashwagandha almost killed my liver – bilirubin hit 50 mg/dL, severe jaundice & itching for months. My warning story (21M)

Replying to Original_Pride_5451 · Carbamide Forte is not a good brand. It could be a brand issue.

I would bet money they have withanone in there, which is known to be hepatotoxic. [DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera \(Ashwagandha\)](https://doi.org/10.1016/j.crtox.2021.02.002) I'll buy some to run…

Ashwagandha almost killed my liver – bilirubin hit 50 mg/dL, severe jaundice & itching for months. My warning story (21M)

Replying to MaintenanceOk7855 · Was it a standardized one you took? Third party lab tested. I guess it's a fair warning for everyone. Hope you are well now and good luck.

He said it was Carbamide Forte, which is a straight up garbage Indian brand. I bet it has withanone in it, which has been shown to be hepatotoxic. I will buy some to run through the lab.

Is nutricost trustable?

Replying to astroturfinstallator · Conflict of interest (buy mine not theirs)

Here are the chromatograms. If I am lying, I can be sued for fraud. I've done this for 13 years now. I've never been sued by any brands that I have released results on. Nutricost had zero saffron bioactives in our recent testing. [Here are the chromatograms from Nutricost's saffr…

How should I go about taking the following supplements from Nootropics Depot? First time purchaser… thanks in advance!

I always take those in the morning. Some people find they can affect sleep if taken later in the day.

Alpha Lipoic acid urine has no smell... valid supplement?

Replying to Snowsunbunny · I contacted the company and they said that the good type the "R-type" does not produce the smell and that other companies simply pretend that they use the R-type when they don't. H…

We have not found that the enantiomer of ALA changes the smell. The only way to know if you have pure R-ALA is running it through a polarimeter. Also, R-ALA is very unstable. You need the sodium salt, Na-R-ALA, for it to be stable. R-ALA freeform will literally melt at 116*F, whi…

SNS Tongkat Ali ..is going to seriously get me introuble. Ridiculous increase in libido

Replying to sawatter · Ok, thanks for the updates. So are you saying that nootropics depot Tongkat Ali has the highest quality amounts, free of hard metals/chemicals etc?

Well yeah, I own Nootropics Depot, and make most of these products so I can personally use them. We hold things to rigorous standards because I feel that's the way it should be, but also because I am putting them into my own body as well.

Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim (2024)

Replying to whereismyface_ig · i better not be spending all this money on mitopure for no reason

LOL! I am going to write the authors and see if they will release the names of the brands tested.

SNS Tongkat Ali ..is going to seriously get me introuble. Ridiculous increase in libido

Replying to sawatter · That seems to be pretty decent then, no?

Yes, it just didn't meet label claim. It's still a good amount of eurycomanone, though. It has about the same eurycomanone as our 2% capsules (we always put more and are over spec on the raws) https://imgur.com/a/4fIaUDe So they have pretty much the same in there as our 2% capsul…

SNS Tongkat Ali ..is going to seriously get me introuble. Ridiculous increase in libido

Replying to sawatter · How’s the testing going, any updates you can share?

They claim 300mg of a 2% eurycomanone extract, which would be 6mg per cap. We found 5.15mg per cap. https://imgur.com/a/6nNpkWc

SNS Tongkat Ali ..is going to seriously get me introuble. Ridiculous increase in libido

Replying to sawatter · Did you get any results back yet?

It was submitted to the lab a few days ago. Should have results soon.