Comment · Wed, February 11, 2026 · Nootropics Depot & Natrium Health
My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)
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biohacker045 · 66 points
What's up boys. I just finished Rhonda Patrick's new episode with Charles Brenner (the guy who discovered nicotinamide riboside, AKA NR). Here's everything I learned. My top 10 takeaways:
1. Ok so first off, buying an "NAD supplement" on Amazon is basically a waste of money. You're much better off buying a precursor (like NR) and supplementing with that to boost NAD. (timestamp)
2. NR is way more effective than that other NAD precursor (NMN). So I'm not an expert but I think NMN is the one David Sinclair preaches about. Charles stressed multiple times that NMN has to be broken down into NR to get into the cell... so you're just better off taking NR. (timestamp)
3. The absolute biggest benefit of taking NR (for healthy people) is exercise recovery. Apparently used to be common in the Patriots locker room under Belichick. So Brady was definitely taking it. There's photos of Charles Brenner and Belichick out there somewhere. (timestamp)
4. Rhonda said she is taking Tru Niagen at the moment (NR) and has been f…
What they were answering
Fragrant-Corner7471 · 2 points
Are you still taking NR?
u/MisterYouAreSoDumb · Nootropics Depot & Natrium Health
Yes, along with NMN and NADH. I am taking our OptiNAD+ stack, which has them all in it, along with other supporting supplements, like CD38 inhibitors.