Comment · Sat, February 14, 2026 · Nootropics Depot & Natrium Health
My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)
Original post in this thread
biohacker045 · 66 points
What's up boys. I just finished Rhonda Patrick's new episode with Charles Brenner (the guy who discovered nicotinamide riboside, AKA NR). Here's everything I learned. My top 10 takeaways:
1. Ok so first off, buying an "NAD supplement" on Amazon is basically a waste of money. You're much better off buying a precursor (like NR) and supplementing with that to boost NAD. (timestamp)
2. NR is way more effective than that other NAD precursor (NMN). So I'm not an expert but I think NMN is the one David Sinclair preaches about. Charles stressed multiple times that NMN has to be broken down into NR to get into the cell... so you're just better off taking NR. (timestamp)
3. The absolute biggest benefit of taking NR (for healthy people) is exercise recovery. Apparently used to be common in the Patriots locker room under Belichick. So Brady was definitely taking it. There's photos of Charles Brenner and Belichick out there somewhere. (timestamp)
4. Rhonda said she is taking Tru Niagen at the moment (NR) and has been f…
What they were answering
Warren_sl · 3 points
Please offer the liposomal NMN/NR as a lozenge or powder. The lipo NMN gel from Renue by science gives the most sustained and fast rush of every I’ve had from any NAD product second to sublingual NMN.
u/MisterYouAreSoDumb · Nootropics Depot & Natrium Health
I believe Renue was using CellG8 as the supplier, which we tested in the lab using the Malvern Nanosight system. We found not only was it not a liposome, it wouldn't even get into solution to properly inject into the machine. We dissolved what we could, which was like 1/4 of the sample, and then 3/4 rest clumped in the test tube. We took the 1/4 that did dissolve and injected it into the Nanosight, and it was 10X larger average particle size than a real liposome. This could be why you don't react orally. At least the sample we got were NOT liposomes. Not sure if they have changed suppliers or not, but this was a year ago or so. You should not have to use sublingual administration with a real liposome.