Comment · Sat, February 14, 2026 · Nootropics Depot & Natrium Health
My top 10 takeaways from Rhonda Patrick's new episode about NAD precursor supplements (NR vs. NMN)
Original post in this thread
biohacker045 · 66 points
What's up boys. I just finished Rhonda Patrick's new episode with Charles Brenner (the guy who discovered nicotinamide riboside, AKA NR). Here's everything I learned. My top 10 takeaways:
1. Ok so first off, buying an "NAD supplement" on Amazon is basically a waste of money. You're much better off buying a precursor (like NR) and supplementing with that to boost NAD. (timestamp)
2. NR is way more effective than that other NAD precursor (NMN). So I'm not an expert but I think NMN is the one David Sinclair preaches about. Charles stressed multiple times that NMN has to be broken down into NR to get into the cell... so you're just better off taking NR. (timestamp)
3. The absolute biggest benefit of taking NR (for healthy people) is exercise recovery. Apparently used to be common in the Patriots locker room under Belichick. So Brady was definitely taking it. There's photos of Charles Brenner and Belichick out there somewhere. (timestamp)
4. Rhonda said she is taking Tru Niagen at the moment (NR) and has been f…
What they were answering
Warren_sl · 2 points
Haha. For what it’s worth I’ve taken up to 500mg of NMNH in a single dose and I didn’t think it was worth the cost over NMN taken orally. I wonder if it would be much better sublingually
u/MisterYouAreSoDumb · Nootropics Depot & Natrium Health
Yeah, that was my read as well. I am considering doing a liposomal NMN, as we did finally find someone making it for real, and doing proper cryoTEM and pharmacokinetic studies. My fight over liposomes wasn't that they were bullshit in theory. It's that nobody was even doing testing to show they were liposomes, much less that they increased bioavailability. With both those done, I am onboard with offering it.