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Comment · Fri, June 3, 2022 · ND Owner

Sigma - New supplement containing Tongkat Ali made in collaboration with A.Huberman.

Original post in this thread

RPher · 51 points

Here is the video presentation by More Plates More Dates, the guy who also sells Turkesterone : https://www.youtube.com/watch?v=mzqI0XEoWes

This is not advertising. I only trust ND products. The reason I'm posting this is because I'm well aware that ND Tongkat Ali is the only one on the market that actually contains a verified and significant amount of Eurycomanone.

But now, there is this new product associated with a big name like A.Huberman. And I would feel very disappointed that even a well respected name like him would be associated with a supplement that contains a crappy Tongkat Ali extract...

So I'm curious, u/NootropicsDepotGuru u/Pretty-Chill u/misteryouaresodumb, what do you think of the formulation of this product ? How likely is it that it contains a legit dose of Eurycomanone? And if you had to make a Natrium Testosterone Booster, what would you do differently ?

What they were answering

Worldly-Education-99 · 1 points

Hi, thanks for your incisive and always interesting comments—you are a hero in this space IMO.

I would like to push back re cistsnxhe

What do you make of this study?

We investigated the effects of Cistanches herba (CH) on the male reproductive system in mice, assessing CREM gene expression and spermatogenesis. Our results demonstrate that CH treatment lead to a significant decrease in sperm count dose-dependently, 298.3 ± 48.9 vs. 296.6 ± 102.4 (250 mg/kg), 236.7 ± 75.1 (500 mg/kg), 223.0 ± 48.7 × 10(6) (1000 mg/kg), respectively. Additionally, serum testosterone levels decreased following CH treatment to as low as ~57% compared with the vehicle-treated group. CREM gene expression was also down-regulated following CH treatment and histological examination of the testicular seminiferous tubules showed severe damage on CH treatment. These results suggest that CH induces cytotoxicity in the male reproductive system, through the inhibition of spermatogenesis, testicular damage, and limited hormonal function.

https://pubmed.ncbi.nlm.nih.gov/22002114/

u/MisterYouAreSoDumb · ND Owner

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