Comment · Fri, March 4, 2022 · ND Owner
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NDSocialMedia · 34 points
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AlwaysWGrace · 3 points
Does NMN have any chance of helping as an anti-inflammatory re auto-immune? Do I need to take the quercetin with it?
u/MisterYouAreSoDumb · ND Owner
Taking quercetin with it is always a good idea, as that is a CD38 inhibitor. That's another piece of increasing NAD+. Also, apigenin is a CD38 inhibitor, too. Taking our Baikal Skullcap with the NMN wouldn't be a bad idea.
NMN can help modulate the inflammatory response by macrophages. It also inhibits the buildup of COX-2, which is pro-inflammatory. I wouldn't necessarily call it an anti-inflammatory. However, it does inhibit inflammation related pathways. Taking it with quercetin will make that even more pronounced, as that has anti-inflammatory actions by modulating leukocytes and targeting many intracellular signaling kinases.