Comment · Sun, February 28, 2021 · Natrium Health & Nootropics Depot
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men: "results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues"
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gintrux · 74 points
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men
In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.
https://sci-hub.do/10.1139%2Fapnm-2016-0178
More studies: https://www.reddit.com/r/Nootropics/comments/gx7pgw/guanidinoacetic\_acid\_precursor\_to\_creatine/
What they were answering
fortis_adipo · 2 points
I haven't, though I would if any consumer vendors sold it (they appear to only be sold by lab vendors).
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
It looks like there are no qualified reference standards for them at the moment, which would make accurate assay of purity difficult. I'll have to speak to my lab director about it.