Comment · Sat, February 27, 2021 · Natrium Health & Nootropics Depot
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men: "results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues"
Original post in this thread
gintrux · 74 points
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men
In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.
https://sci-hub.do/10.1139%2Fapnm-2016-0178
More studies: https://www.reddit.com/r/Nootropics/comments/gx7pgw/guanidinoacetic\_acid\_precursor\_to\_creatine/
What they were answering
fortis_adipo · 1 points
To my knowledge, they're weak AMPAkines. I was thinking of ones like CX-717/CX-1739, ORG-26576, etc.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Those are definitely stronger. I have not personally tried any of those, though. Have you? What has been your experience?