Comment · Thu, February 11, 2021 · Natrium Health & Nootropics Depot
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men: "results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues"
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gintrux · 74 points
Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men
In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues.
https://sci-hub.do/10.1139%2Fapnm-2016-0178
More studies: https://www.reddit.com/r/Nootropics/comments/gx7pgw/guanidinoacetic\_acid\_precursor\_to\_creatine/
What they were answering
fortis_adipo · 3 points
We need to find a way to directly buy NAA.
Sigma Aldrich sells it, but they only sell it to approved labs/institutions. I wish a nootropics vendor would start selling it. u/misteryouaresodumb thoughts?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
I will have to look into it. It's not a common amino acid I have run into before, so it might have to be a custom synthesis.