Comment · Mon, September 9, 2019
Any Plans for Optimized D3?
Original post in this thread
AromaticAminoAcid · 4 points
Does D3 benefit from a specialized delivery, or a particular type of lipid? Seems to be especially synergistic with chocolate.
What they were answering
ar-jan · 2 points
ha, that reminds me of the story of Abbott's disappearing Norvir drug
> “We tried everything. We conducted countless experiments. We reconditioned our facilities. We rebuilt facilities and new lines. We looked at alternative sites. We visited a number of [other] organizations around the world…to see if we could start clean in a new environment free of Form II. In amatter of weeks—maybe five or six weeks, every place the product was became contaminated with Form II crystals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479028/
u/MisterYouAreSoDumb
That's really interesting!
A broad range of crystallization techniques is generally employed to search for the most stable crystal form in hundreds or (in some cases) thousands of experimental attempts. New crystal forms can, however, emerge unexpectedly long after the carefully designed and executed screening experiments are completed. Such a sudden emergence of a new crystal form can be unsettling and problematic, especially in the late stages of a product development or even following launch, because the newly emerged form can exhibit different (possibly undesired) properties.
Most people are not even aware of polymorphs, much less how much they can affect all sorts of things. It's literally the only thing left to explain the differences in adrafinil. I thought that maybe the higher iron one was attracting more of a specific isomer, but we did rotational analysis on both batches and they are both identically racemic. So the only thing left is X-ray crystallography to see if there are polymorphism differences.