Top 10 nootropics

Comment · Mon, April 11, 2016 · 2 pts

My supplementation regimen is not scientifically proven, nor should it be used as a claim that you can prevent 100% of the neurotoxicity risk. It's meant as a harm-reduction strategy for those choosing to use MDMA anyway

Comment · Mon, April 11, 2016 · 7 pts

>Previously I had convinced myself (mainly via reading things on the internet and hearing what others said about it) that it was totally harmless and "safer than horse riding or alcohol". That pisses me off so much. I t

Comment · Tue, April 12, 2016 · 2 pts

LSD and traditional psychedelics are not neurotoxic. However, they can cause HPPD and psychological issues if not done in the proper environment.

Comment · Tue, April 12, 2016 · 2 pts

It would be a familiar environment, with people that you trust, and in a proper mindset. Having some Xanax on hand is a good idea too, if things get out of control. You want your environment to be as familiar and safe as

Comment · Thu, April 14, 2016 · 1 pts

Correct. Psychedelics will down-regulate serotonin receptors. That is what is causing tolerance. Even MDMA only acutely depletes serotonin stores by 15-20%. It's the down-regulation of tryptophan hydroxylase that eventua

Comment · Thu, April 14, 2016 · 1 pts

Yeah, that is a good way as a last ditch effort. It completely aborts it, though. Xanax just calms you down.

Comment · Fri, April 15, 2016 · 1 pts

No, not always. Nicotine actually up-regulates ACh receptors, but desensitizes them. They are different mechanisms. Up-regulation of serotonin receptors is usually done with Saint John's Wort.

Comment · Wed, April 20, 2016 · 1 pts

There are a few possible mechanisms for HPPD. The most likely is excitotoxicity in the neurons that control visual and auditory processing. Excitotoxicity is caused by excess glutamatergic signaling, which can be exacerb

Comment · Thu, April 21, 2016 · 2 pts

Well that's just another jump in assumptions. Benzos act directly on the GABA system. Selank's actions are a lot different. Could they help? Possibly. However, there is no evidence of that yet. If the theory is correct,

Comment · Thu, April 21, 2016 · 1 pts

If the excitotoxicity theory of HPPD is true, perhaps. The issue is that DXM is mostly a serotonin re-uptake inhibitor. Its metabolite DXO is actually the NMDA antagonist. So DXM is going to interact with a lot more syst

Comment · Thu, April 21, 2016 · 1 pts

Yeah, curcumin might help. Longvida would be the best to reach the brain. It protects from excitotoxicity by modulation of the NR2A subunit of the NMDAr. >And what about taking glutamatergics and ampakines not at the tr

Comment · Wed, June 8, 2016 · 2 pts

[Hallucinogen persisting perception disorder: what do we know after 50 years?](http://www.sciencedirect.com/science/article/pii/S037687160200306X) [Exacerbation of Hallucinogen-Persisting Perception Disorder With Risper

Comment · Thu, June 9, 2016 · 1 pts

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736944/ That one talks about it in more detail. This one too: http://psychonautdocs.com/docs/abraham_psychopharma.pdf >It was theorized that these visual disturbances repr