Hydrafinil - New Modafinil Analogue

Comment · Wed, August 20, 2014 · 12 pts

Hydrafinil sounds much better than 9-hydroxyfluorene. You have to admit that. We have another analog in the works too that we came up with a name for. But that one literally has no name, so we had to.

Comment · Wed, August 20, 2014 · 2 pts

We are not giving dosing advice, but merely making parallels to modafinil dosing. I altered the words a bit to be more clear.

Comment · Wed, August 20, 2014 · 2 pts

The tired feeling is dose-dependent, and does not happen for everyone. Some of our testers did not have any crash at all, even at high dosages. So we are going to have to see how everyone reacts.

Comment · Wed, August 20, 2014 · 10 pts

Well it is not a random research chemical. Cephalon is considering this to be a modafinil successor, and has put it through some trials. But I do see your point.

Comment · Wed, August 20, 2014 · 5 pts

/u/silverhydra was talking to me about that the other day. Seems like an interesting natural DRI. I have not looked into theacrine yet. We have a lot more natural stuff coming out too. We just promised to come out with

Comment · Wed, August 20, 2014 · 13 pts

I will put up a red warning on the site, so people know this is brand new and untested in humans. You are right, we need to make sure it is clear that there is not a lot of data on this substance.

Comment · Wed, August 20, 2014 · 1 pts

Not this version. It is not soluble enough. We may be exploring creating a salt, to increase solubility.

Comment · Wed, August 20, 2014 · 8 pts

Noted. I never considered that.

Comment · Wed, August 20, 2014 · 4 pts

It's a 5-HT6 antagonist. Those do not interact with SSRIs to my knowledge. Antagonism of the 5-HT6 receptor increases dopamine and norepinephrine release in the frontal cortex. It's not going to lead to any serotonin int

Comment · Wed, August 20, 2014 · 1 pts

Isn't tomatine an antifungal found in tomatoes?

Comment · Wed, August 20, 2014 · 4 pts

Square denied us a long time ago, along with most other well known processors. The "pseudo pharmaceutical" market is too risky, it seems.

Comment · Wed, August 20, 2014 · 9 pts

SilverHydrafloo

Comment · Wed, August 20, 2014 · 2 pts

We ship to the UK, and have shipped to Germany before. We are looking into having a reshipper in the EU for the stricter countries like Norway.

Comment · Wed, August 20, 2014 · 1 pts

This is just our first analog. We have a couple more on the horizon, but lab issues increased the cost, and put delays on it. I do not think this is the end all and be all of the eugeroics. This is just step one. I am ve

Comment · Wed, August 20, 2014 · 1 pts

I'm not familiar enough with depakote to say. Venafaxine might make the effects more pushy, due to the increased norepinephrine. Honestly I would not be comfortable saying whether she could use it or not. It might be fin

Comment · Wed, August 20, 2014 · 4 pts

If I take modafinil any time after 10am, I won't be able to go to sleep till 1 or 2am. For me it is way too long of effects.

Comment · Wed, August 20, 2014 · 3 pts

Efficacy and potency are different. If it was 140% potency, then you would be correct. But efficacy is more to do with peak effects, rather than dosages.

Comment · Wed, August 20, 2014 · 3 pts

I should have said was considering it. They've moved to a new analog that is more efficacious. We should be getting that one in too, once we work out the synthesis issues. This is just the first one we were able to get s

Comment · Wed, August 20, 2014 · 3 pts

Were developing. They've moved to a different compound now. We should get that one in as well, but did not want to make people wait any longer. That's why we had Hydrafinil synthesized, as a first step into the eugeroic

Comment · Wed, August 20, 2014 · 3 pts

The other compound is 200% the effectiveness of modafinil, as opposed to 140% as effective. So they were just going after the more efficacious molecule.

Comment · Thu, August 21, 2014 · 2 pts

There is too little data to say for sure. I personally cannot use modafinil every day. There are too many side effects. But I did not have those same side effects on hydrafinil. It was a lot smoother for me.

Comment · Fri, August 22, 2014 · 2 pts

Probably due to increased glutamate. I would bet you are defficient in magnesium. Take a bioavailable magnesium supplement, like glycinate, citrate, L-threonate, etc. Then see how you react. Hydrafinil does not seem to

Comment · Sun, August 24, 2014 · 2 pts

I think that one was around 8 hours, if I remember correctly. The synth is a lot harder, and much more expensive, though. We will hopefully work through those issues.

Comment · Sun, August 24, 2014 · 1 pts

Cephalon has moved on to a more potent analog. We are working on that one too. But no, they have not patented it yet. They have made some of the data public, though.

Comment · Sun, August 24, 2014 · 2 pts

Me too. I don't really like modafinil. It does not play nicely with other things. I can't drink on it. I can't take other stims on it. I stay up way too late reading and typing long rants. This one has none of that. Just

Comment · Tue, August 26, 2014 · 1 pts

Perhaps. There is not enough data to say for sure. But I would assume the ultimate wakefulness promotion mechanism is the same for both substances. That would mean the variability is most likely similar.

Comment · Tue, August 26, 2014 · 1 pts

Yes, it is a very strange texture. It is also not soluble in really anything. We would love to make a sublingual solution out of it, but it will not play nicely with anything. We thought we might be able to make a salt w

Comment · Tue, August 26, 2014 · 1 pts

Definitely let me know how you like it. It sounds like it might fit the bill for what you need.

Comment · Sat, September 6, 2014 · 1 pts

Just because something is a P450 enzyme, does not mean it is found primarily in the liver. That study is saying that P450 oxygenase converts the hydroxyl group of 9-fluorenol to a ketone, making 9-fluornenone. However, t