Comment · Thu, October 31, 2013 · Ceretropic
IDRA-21 Safety
Original post in this thread
pidginduck · 35 points
I haven't seen any studies that show safety for chronic/long-term use. Now that NSN is selling IDRA-21, I think it is important we talk about its safety profile. This paper should be of concern.
Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo.
It is likely that in hippocampal neuron cultures other AMPA receptor modulators with similar physiological actions as CYZ, diazoxide, IDRA 21 and 1-BCP would also exhibit AMPA receptor-mediated excitotoxicity.
The author of that article is also the one that wrote that IDRA-21 potentiates neurotoxicity during ischemia, strokes, and seizures. This is interesting because that is the opposite effect that -racetams have. Piracetam lessens damage from strokes and cerebral ischemia
What they were answering
thegrumpyhypnotist · 1 points
Do you consider Aniracetam to fall into the category of "stronger AMPAkine" in this context? What about Coluracetam?
u/MisterYouAreSoDumb · Ceretropic
No, aniracetam is not a strong AMPAkine. There is not enough information on coluracetam's AMPA affinities for me to say. However, from anecdotal experience, it does not lead to adverse effects I would associate with excitotoxicity. So I would say no, it's not that strong of an AMPAkine.