Comment · Wed, October 30, 2013 · Ceretropic
IDRA-21 Safety
Original post in this thread
pidginduck · 35 points
I haven't seen any studies that show safety for chronic/long-term use. Now that NSN is selling IDRA-21, I think it is important we talk about its safety profile. This paper should be of concern.
Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo.
It is likely that in hippocampal neuron cultures other AMPA receptor modulators with similar physiological actions as CYZ, diazoxide, IDRA 21 and 1-BCP would also exhibit AMPA receptor-mediated excitotoxicity.
The author of that article is also the one that wrote that IDRA-21 potentiates neurotoxicity during ischemia, strokes, and seizures. This is interesting because that is the opposite effect that -racetams have. Piracetam lessens damage from strokes and cerebral ischemia
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
AMPA-mediated excitotoxicity is not fully understood, as most of the focus on CA^2+ damage is limited to the NMDA receptors. That is what memantine helps to protect. So my logic would be to find a memantine-like substance that selectively binds to the CA^2+ permeable AMPA receptors. Perhaps NASPM.
But yes, AMPA excitotoxicity is definitely a concern with stronger AMPAkines like IDRA-21.