Comment · Thu, October 31, 2013 · Ceretropic
IDRA-21 Safety
Original post in this thread
pidginduck · 35 points
I haven't seen any studies that show safety for chronic/long-term use. Now that NSN is selling IDRA-21, I think it is important we talk about its safety profile. This paper should be of concern.
Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo.
It is likely that in hippocampal neuron cultures other AMPA receptor modulators with similar physiological actions as CYZ, diazoxide, IDRA 21 and 1-BCP would also exhibit AMPA receptor-mediated excitotoxicity.
The author of that article is also the one that wrote that IDRA-21 potentiates neurotoxicity during ischemia, strokes, and seizures. This is interesting because that is the opposite effect that -racetams have. Piracetam lessens damage from strokes and cerebral ischemia
What they were answering
thegrumpyhypnotist · 1 points
Thanks for the input! That's a relief, and another reminder that "stronger" isn't necessarily better.
u/MisterYouAreSoDumb · Ceretropic
Smarter is always better!