Comment · Thu, October 31, 2013 · Ceretropic
IDRA-21 Safety
Original post in this thread
pidginduck · 35 points
I haven't seen any studies that show safety for chronic/long-term use. Now that NSN is selling IDRA-21, I think it is important we talk about its safety profile. This paper should be of concern.
Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo.
It is likely that in hippocampal neuron cultures other AMPA receptor modulators with similar physiological actions as CYZ, diazoxide, IDRA 21 and 1-BCP would also exhibit AMPA receptor-mediated excitotoxicity.
The author of that article is also the one that wrote that IDRA-21 potentiates neurotoxicity during ischemia, strokes, and seizures. This is interesting because that is the opposite effect that -racetams have. Piracetam lessens damage from strokes and cerebral ischemia
What they were answering
xsiv1 · 1 points
Thanks for the response and now I understand. I was wondering why I was down voted when I was asking a question and stating that I wouldn't think either would be suitable for consistent use. I know huperzine a should definitely not be taken with an acetylcholine precursor.
u/MisterYouAreSoDumb · Ceretropic
Don't pay much attention to downvotes. Most people are retarded. Your post was on-topic and relevant.