Comment · Thu, October 31, 2013 · Ceretropic
IDRA-21 Safety
Original post in this thread
pidginduck · 35 points
I haven't seen any studies that show safety for chronic/long-term use. Now that NSN is selling IDRA-21, I think it is important we talk about its safety profile. This paper should be of concern.
Thiazides also dramatically increase AMPA receptor-mediated neuronal death in vitro and in vivo.
It is likely that in hippocampal neuron cultures other AMPA receptor modulators with similar physiological actions as CYZ, diazoxide, IDRA 21 and 1-BCP would also exhibit AMPA receptor-mediated excitotoxicity.
The author of that article is also the one that wrote that IDRA-21 potentiates neurotoxicity during ischemia, strokes, and seizures. This is interesting because that is the opposite effect that -racetams have. Piracetam lessens damage from strokes and cerebral ischemia
What they were answering
xsiv1 · 3 points
Would the sporadic use of IDRA 21 and say, Huperzine-A as a neuroprotectant allow for it's "safer" use? (Both, at least to me, shouldn't be used regularly from what I've been reading)
u/MisterYouAreSoDumb · Ceretropic
It is postulated that Huperzine-A may antagonize NMDA receptors, protecting from excitotoxicity. However, the risk of IDRA-21 induced excitotoxicity is limited to the AMPA receptors. So no, I do not think Hup-A would help in this case.