Comment · Tue, August 13, 2013 · Ceretropic
L-Phenylalanine , L-Tirosine , L-DOPA
Original post in this thread
Christos85 · 13 points
Can you please tell me why some people from here are using L-Phenylalanine and L-Tirosine instead of just using L-DOPA ? (L-Phenylalanine - while in the body - its biologically converted to L-Tirosine which in turn its biologically converted into L-DOPA which is further converted into dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). )
What they were answering
Nefera3 · 3 points
The only part that confuses me is this "Then you are going to need one for the frontal cortex. Agomelatine has been shown to increase BDNF in the frontal cortex, as has low doses of THC."
Can you please tell me how many mg of agomelatine should be used per day and more importantly why ?
Thanks a lot for your help.
u/MisterYouAreSoDumb · Ceretropic
Here is a study regarding agomelatine
MDMA's metabolites can cause oxidative stress in many parts of the brain. The two most hit are the hippocampus and the frontal cortex. The hippocampus is more concerned with memories and learning, so that is why former heavy MDMA users show lower scores on memory tests. Then the frontal cortex is more associated with higher cognitive functions and mood. This is why former heavy MDMA users have mood regulation issues. If enough oxidative stress happens, the axon terminals for the 5-HT neurons can get damaged or destroyed. BNDF is the body's transmitter than stimulates neuronal growth, so increasing it in the frontal cortex and hippocampus can help in the repair and reformation of axon terminals that were damaged by MDMA's/Amp's metabolites.
Normally the dosage for agomelatine in humans is 25mg. That should be sufficient to help increase BDNF. Although even extremely low doses of THC have shown to do the same thing.
http://www.nature.com/npp/journal/v31/n2/full/1300871a.html
http://www.ncbi.nlm.nih.gov/pubmed/22821081