Comment · Sun, December 2, 2012 · Ceretropic
Hypomanic modafinil rebound
Original post in this thread
MisterYouAreSoDumb · 3 points
I had a very interesting interaction a couple days ago. I had been taking 75mg D-modafinil every day for 5 days, while ceasing my caffeine supplementation. I got back home from Thanksgiving in Colorado, and decided to drop the modafinil and return to my normal stack.
In the morning I took:
200mg caffeine
10mg noopept
500mg bacopa
120mg ginkgo
500mg ALCAR
150mg Na-R-ALA
200mg magnesium glycinate
200mg EGCG
500mg quercetin
sublingual B complex
1,600mg piracetam
_________________________________________________
Well this resulted in a first class ticket to hypomaniaville! It must have been a rebound effect from adding caffeine back in with the residual effects from the modafinil. I am pretty certain it has something do do with modafinil's induction of certain CYP450 enzymes. It was not unpleasant, and I was fully aware of what was going on. In fact, it was extremely enjoyable. I had dopamine/serotonin tingles shooting through my head all day long. It literally felt like I had taken MDMA. The next day I kept my stack exactly the same, but it did not lead to the same result. It worked, but more from a focused standpoint.
Anybody else have a similar effect from modafi…
What they were answering
AtomikPi · 1 points
200 mg caffeine is a hearty dose if you don't have a tolerance. As someone who uses caffeine once a week or so, 200 mg would elevate my mood pretty dramatically.
There's also a possibility of potentiation from piracetam (potentiates stimulants), ALCAR (acts largely as a stimulant, admittedly a weak and complex one, with additional non-stimulant effects), B (methylation can increase NT levels), and quercetin (has MAOI activity).
u/MisterYouAreSoDumb · Ceretropic
Yeah, but I take caffeine every day. I have a pretty good tolerance. The other supplements were part of my stack before modafinil. The only change was that I switched oxiracetam to piracetam, which should have less potentiation. I also had been taking modafinil for 5 days. I am pretty certain it was an interaction from having taken the modafinil.
That stack has been working very well for me, lowering stress and improving focus. Occasionally I get a little hypomanic and excited on it. However, nothing compared to this. I had full on head tingles throughout the whole day. If you can think of another explanation, please share it. I would be very surprised if it was the switch from oxiracetam to piracetam that did it, but who knows.