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382 matches · P21
Why the difference in reviews on Reddit vs. Amazon for MicroMag?
Replying to Happy-Walk3489 · Hey, I saw one of your posts on P21 from 12 years ago when you were taking it. Are you still taking it and what did you notice?
Yeah, we were the first company to ever release P21. It's a really cool peptide. I ever developed entirely new peptides based on what we learned from it, like Adamax. That's my peptide that I created and named. I also made other ones we never released that are even better. No, I…
ND & Greg Doucette Partnership…
Replying to P21throwaway · P21?
We were the first to bring out P21. However, I made my own new peptide that I named CEN-1. P21 was what inspired me, though.
Life ruined from permanent sexual dysfunction from antidepressants. Help!!
Replying to Beginning-Wind-371 · and **CNTF** just like your P21! >Consistent with the increased synthesis of DNA in RSC96 cells, Andro was able to upregulate the mRNA expression levels of BDNF, GDNF and **CNTF**…
Right? Andrographis a really cool one that I take every day. It doesn't get the attention it deserves.
🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬
Replying to Chargers95 · CNTF is the growth factor key in the survival of new neurons, correct? Edit: it’d be interesting if you guys could find a natural product that could increase CNTF similarly to P21…
Yes, CNTF is a crucial for the growth of astroglia. It's one of the critical neurotrophic factors in the brain. Many people focus on BDNF and NGF, but CNTF and GDNF are both crucial, too.
🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬
Replying to eamonn123 · Wow! Any other substances you know of that increase CNTF?
The peptide P21 does, but I can't think of other natural supplements that do.
What's your favorite Noot from ND and why?
Replying to fascist_horizon · adamax or p21
Those are technically "my" peptides, but certainly not ND. LOL
7, 8-Dihydroxyflavone WTF
Replying to Beginning-Wind-371 · Do you know if N-PEP-12, or MEMOPROVE, is as effective as IM Cerebrolysin? I do remember you being skeptical a couple years ago and made P21. I know that most peptides are not as e…
No way those small oral peptides are anywhere near IM Cerebrolysin or sub-Q P21.
Lion's Mane: ND vs RealMushrooms
Replying to tylerdurden1585 · Hi. Do you know anything about Peptide 6C, an apparent derivative of P21 that is bring sold by cziom. I can't gind anything online. Thanks so much for sharing your knowledge
That doesn't look like a reliable vendor. There are no 3rd party labs giving them COAs for those products. They are just lying and hoping people won't call them out about it. Ask them for one of the 3rd party COAs, and send it over to me. Peptide 6C is just a shittier version of…
p21 any balding side effects?
Replying to RX_btw · /u/misteryouaresodumb any experience here? or know of any stories from other people over the years
I have not noticed any hair changes from P21. The people that have had that effect usually see it from Semax, which hits BDNF. However, it is a rare effect from what I have seen.
Some info before next order
Replying to GNATUS_THYRSI · With all due respect, how is berberine safer than metformin? Metformin is rather well studied. More natural? Keeping BG even is one goal, but insulin itself is problematic, so t…
Did you read the study I linked above? It goes into great detail, and there are a ton of other studies on berberine. Also, there is evidence that berberine either has no effect on insulin levels, or lowers them. [Effects of Berberine on Glucose Metabolism In Vitro](https://sci-hu…
Herbal GABAergics and dependency
Replying to Silver-Interaction-2 · >CNTF What nootropics hit CNTF besides Cerebrolysin/P21?
[Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes](http://europepmc.org/articles/pmc4644097?pdf=render)
4’-DMA-7,8-DHF 30caps now live!
Replying to srubek · I'm so happy, I'm already debating ordering yet another 90ct. Fastest I've ever ordered something from you, from seeing this post, to ordering completion. This feels like a new ver…
Thanks, man! I am glad we can keep pushing forward on these novel things!
Can I megadose the black seed extract ? + need some recommendation.
Replying to xyz679 · Perhaps u/MisterYouAreSoDumb given his experience with taking and quitting kratom can help? I recall MYASD has posted somewhere at some point in the past what he took and why to co…
Semax, Selank, P21, and tianeptine were the ones I talked about in that old post. Nigella sativa can absolutely help as well. Agmatine sulfate, too.
Amount of piperine to inhibit CYP3A4?
Replying to xyz679 · >I would personally avoid piperine in that instance. I actually suggest avoiding inhibiting CYP enzymes at all these days. Oh, what changed? I thought you've had it figured out th…
>Oh, what changed? I thought you've had it figured out that preventing the metabolism to MDA would prevent a lot of the neurotoxicity. Just wondering how it all works if its not too much to explain. That was my theory from years ago. I have learned a lot since then. I still think…
Has taking nootropics changed the way you perceive reality?
Replying to LockeHardcastle · Out of curiosity, may I ask which tools you prefer, personally?
Legal: Semax and its derivatives, P21, Epitalon, 7,8-DHF, lion's mane, polygala, nigella sativa, coluracetam/fasoracetam/pramiracetam/oxiracetam, other stuff we have created and are working on in the background. Not so legal: MDMA, LSD, 4-ACO-DMT It's also less about the end resu…
Piracetam situation? (125g jars back in stock)
Replying to Muffinman392 · Thats cool af that you guys are making new molecules, the nootropics scene has been lacking in terms of innovation.
We created phenylpiracetam hydrazide back in the Ceretropic days. I found the research on piracetam hydrazide, and figured why not add a phenyl group? So we contracted a lab to make it for us. N-acetyl semax and N-acetyl semax amidate were us, too. All the acetylated and amidated…
Why isn't Lion's Mane suggested in ND stack recommendations for promoting neuroplasticity?
Replying to eamonn123 · What would be the best neuroplasticity stack in your opinion?
Ohh man, that's a tough one. Maybe lion's mane, 7,8-DHF, polygala, and surprisingly berberine. Then you are hitting NGF, BDNF, and sigma-1. The other one to target would be CNTF. I'd have to think about what supplement would be best for that. The best synthetic for that is the P2…
Immune Defense & positive blood test results
Replying to sirsadalot · Sucks to hear that you have to resort to using kratom. I'm not gonna lie, I'm a little disappointed about that. Have you ever tried bromantane, or other things for dopamine synthes…
It is what it is. The oxycodone after my shoulder surgery is the real culprit in all this. That's what led to the changes in my brain, and I have been dealing with that ever since. I have gone off kratom completely a few times without issue, though. Now it is more a choice to ope…
Immune Defense & positive blood test results
Replying to [deleted] · [deleted]
>I bet everything you have done originated in your mind as a thought first, right? Absolutely. I can't even begin to explain all the things I think about and analyze. My brain is constantly doing it. Sometimes it can be exhausting. >What's the best supplement / drug etc you have…
What reshipper is best for sending ceretropic.mx to US?
Replying to MickeySabbath420 · Fair point. Of course, with regular access to Ceretropic's Semax, Selank, p21, NASA, and NA-Selank... frankly, Scarlett, no me importaria un comino.
LOL, true!
ReachGenius is claiming to sell the original P-21, can anyone here verify if it's authentic?
Replying to gf337 · Mister, the question is... is there any legitimate P21 still out there somewhere? Direct from china suppliers maybe? I use your products as well man. good shit.
Unfortunately not. Nobody is properly testing peptides at the moment.
ReachGenius is claiming to sell the original P-21, can anyone here verify if it's authentic?
Replying to gf337 · Not even direct from the suppliers in china? are they really all that sketchy?
Yes, they really are. There's no incentive for quality when nobody holds them accountable.
Does Adamax upregulate Trkb to the same degree as Semax?
Replying to germaneman · Nice response! Grateful. I take Berberine and resveratrol daily as part of my staple stack. I’ll order some polygala from ND as a tribute and add that one to the mix. For some rea…
It's probably the MAOI effects from them. I get that too if I add in carnosine to the mix. I came up with Adamax myself based on some assumptions regarding it in comparison to P21. We can speculate on how it acts, but we don't have direct scientific data. So I can't say for sure.…
ReachGenius is claiming to sell the original P-21, can anyone here verify if it's authentic?
Replying to Amesharea · Would you be so nice and maybe tell us, where you get your peptides from, if you still use any? There are no reputable sources I know of...
There are no reliable sources for peptides at the moment, unfortunately.
ReachGenius is claiming to sell the original P-21, can anyone here verify if it's authentic?
Replying to Pretty-Wolf · >So they are FINALLY admitting to selling fake P21 all these years... Modified P21? LOL. Why not just call it what it actually was, improperly made. The Chinese supplier they use g…
I posted about it on here literally the month they started selling it. Everyone selling P21 was selling this fake peptide. It was much easier and cheaper to make. Adding in an alanine in place of a very unique adamantyl-glycine moiety is about as simple as it gets. If these fucki…