Comment · Sun, February 9, 2020 · Natrium Health & Nootropics Depot
ReachGenius is claiming to sell the original P-21, can anyone here verify if it's authentic?
Original post in this thread
Polynomality · 8 points
From I understand this one has the dimer in its structure while the modified version doesn't, which supposedly changed the peptide's properties...?
Either way, I would like to hear your reviews please.
What they were answering
Pretty-Wolf · 4 points
So they are FINALLY admitting to selling fake P21 all these years... Modified P21? LOL. Why not just call it what it actually was, improperly made. The Chinese supplier they use got confused by the way I typed the adamantane in the sequence (aG), and switched it out with alanine. Everybody just tried to copy what I did at Ceretropic, but they were too dumb to even make it look like they did it right. That Chinese supplier tried to sell it to us way back in the Ceretropic days, and we caught that they had totally fucked up and created a whole different peptide instead. I've literally told everyone this for years now. They had the damn mass spec up with the wrong mass the whole time! They were calling it P21, and selling that fake P21 to countless customers... Now they suddenly fixed it! Ohh, why not fucking sell the old fake P21, too! Let's just call it modified! Wouldn't want to lose money on those batches. Nobody died from it... at least that we know of. What a fucking joke.
Are you really considering still buying from a company that couldn't even get the mass on the COA correct for the peptide FOR YEARS?!? Not only that, when they finally admit it was not real P21, they keep selling the improperly produced peptide as a separate product?!? Jesus tapdancing Christ, you guys are injecting this into your bodies! They are not even smart enough to fake a COA with the corre…
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
I posted about it on here literally the month they started selling it. Everyone selling P21 was selling this fake peptide. It was much easier and cheaper to make. Adding in an alanine in place of a very unique adamantyl-glycine moiety is about as simple as it gets. If these fucking idiots really wanted to make a modified version, they would have just chopped off the entire moiety altogether and amidated it. I did it years ago. I made tons of modified things to personally try out. They are literally too stupid to understand how these peptides are working in the body, though. They don't fucking know what the adamantane is doing, or why its there. They don't understand that adding in an alanine-glycine at the end can totally fuck up its pharmacokinetics and pharmocodynamics in the body. You've now taken a 4 mer peptide and made it a 6 mer. What position the enzymes and proteases in the body cleave it is now just a guess. Could you get EXTREMELY lucky, and have it cleave at the alanine and leave the DGGL intact? Very unlikely. Even then, that small Alanine-Glycine peptide fragment is going to do something in the body. What if it cleaves down the middle? Now you have two separate peptides of Aspartic acid-Glycine-Glycine and Leucine-Alanine-Glycine. What are those two tripeptides going to do in the body and brain? It's anyone's guess. If they really wanted to make a modified version, Ac-DGGL-NH2 is the simplest way to get rid of the complicated moiety, but keep the actual affinities in place. If they just read the damn study on P21 they would know that. They are idiots, though. They also didn't mean to make the modified P21. It was a mistake. To play it off as anything else is just shady. They are only in it to make money, like everyone else left in that side of the industry. They copy people who they think are successful, but they don't have the mental capacity to understand what they are doing.