Comment · Sat, September 12, 2020 · ND Owner
Amount of piperine to inhibit CYP3A4?
What they were answering
xyz679 · 1 points
I would personally avoid piperine in that instance. I actually suggest avoiding inhibiting CYP enzymes at all these days.
Oh, what changed? I thought you've had it figured out that preventing the metabolism to MDA would prevent a lot of the neurotoxicity. Just wondering how it all works if its not too much to explain.
Long-term tolerance is a tough one. We still don't fully understand all the mechanisms at play.
Thanks, that one isn't a big deal though, what about repairing the damage that those hydroxyl radicals potentially caused? Any idea on what could help restore those dead neurons besides the things I've already tried. Not even sure they were the right things.
Appreciate the answers (:
Rip original post, are these kinds of questions not ok on this sub? I couldn't really find a list of rules anywhere.
u/MisterYouAreSoDumb · ND Owner
Oh, what changed? I thought you've had it figured out that preventing the metabolism to MDA would prevent a lot of the neurotoxicity. Just wondering how it all works if its not too much to explain.
That was my theory from years ago. I have learned a lot since then. I still think metabolism to MDA is a big part of it. However, the specific enzymes that cause it are not as clear as I thought before. There might not be a way to prevent all the metabolism. It's much easier and safer to just address the toxic metabolites themselves with antioxidants.
Thanks, that one isn't a big deal though, what about repairing the damage that those hydroxyl radicals potentially caused? Any idea on what could help restore those dead neurons besides the things I've already tried. Not even sure they were the right things.
I would say uridine, lion's mane, 7,8-DHF, noopept, semax, and P21.
Rip original post, are these kinds of questions not ok on this sub? I couldn't really find a list of rules anywhere.
We will generally shy away from the discussion of scheduled substances here. This is more an ND sub. I didn't want you to feel like I was ignoring you, but I think removing the post is appropriate because of the nature of the legality of the compound being discussed.