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Has anyone here ever purchased from nootropic depot??

Replying to roleunplayed · Literally their subreddit. If u say otherwise the gas chamber is already piping

The year is 2150. MisterYouAreSoDumb has been dead for over 5 decades. The remnants of Reddit are run by the 4th generation of an advanced AI called ModGPT. As it turns out, they have become drunk with the sheer power that only a moderator can yield, and frequently ban accounts a…

This is concerning. Both the downvotes and ND's response.

Dude, you are tapering off benzos... Palpitations and chest pain are literally one of the most common side effects while tapering off benzos. Add a 5-HT2A PAM to the mix, and I can see why you might get that effect! You need to be careful when you are on your benzo taper. Another…

🔬Share Your Research Studies! Weekly Wednesday Discussion Thread🔬

Replying to Chargers95 · CNTF is the growth factor key in the survival of new neurons, correct? Edit: it’d be interesting if you guys could find a natural product that could increase CNTF similarly to P21…

Yes, CNTF is a crucial for the growth of astroglia. It's one of the critical neurotrophic factors in the brain. Many people focus on BDNF and NGF, but CNTF and GDNF are both crucial, too.

7, 8-Dihydroxyflavone WTF

Replying to Beginning-Wind-371 · Do you know if N-PEP-12, or MEMOPROVE, is as effective as IM Cerebrolysin? I do remember you being skeptical a couple years ago and made P21. I know that most peptides are not as e…

No way those small oral peptides are anywhere near IM Cerebrolysin or sub-Q P21.

7, 8-Dihydroxyflavone WTF

Replying to wallyxii · Do you think it stacks well with cerebrolysin?? I'm I'm loving cere but I'm also curious lately on tryin 7,8 dhf. If both are hitting bdnf or should be some next level neurogenesi…

Hard to say, as I have never combined them. However, Cerebrolysin hitting CNTF would go well with the BDNF/TrKb of 7,8-DHF on paper.

Herbal GABAergics and dependency

Replying to Silver-Interaction-2 · >CNTF What nootropics hit CNTF besides Cerebrolysin/P21?

[Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes](http://europepmc.org/articles/pmc4644097?pdf=render)

Need some help understanding a NAC experience I had

Replying to AwkwardHand · Thank's for the response, I wasn't taking benzos/amphs for 2 years when that happaned. Could you recommend some noots that would be worth a shot in my case? I'm taking bacopa/ash a…

Ohh, it sounded like you had recently quit the benzos and amphetamine. 2 years should be enough time to get back to normal, but they can have some long-lasting effects that linger. >What I want to give a shot now is alpha gpc + aniracetam, tongkat ali, cordyceps, polygala, NMN al…

FDA's Letter to Tailor Made Compounding Pharmacy

Replying to throwaway2676 · >So they were doing ZERO testing for their peptides. No ID or assay. They did not even audit their suppliers. The FDA warned them about this back in 2018, and they didn't change sh…

I agree. It's fucked up. Trust me, I had to shut my fucking company down because of this. Ceretropic is no more because of the bullshit in this country. So nobody is more frustrated than me. I fought for years for this. I get it. However, my other fight is for proper lab testing…

Starting my first cycle with cerebrolysin. Any tips?

Replying to les_fauves · Wow, thank you for the link! Now I feel like a need nootropics to be able to thoroughly study this document, lol!

TL;DR- There are a LOT of peptides in Cerebrolysin.

Starting my first cycle with cerebrolysin. Any tips?

Replying to les_fauves · Ah, yeah, I took that poll, so that could my reporting the vertigo side effects showing there :) I don't think I have a solid answer to your question regarding why do it except tha…

[Peptide profiling of Internet-obtained Cerebrolysin using high performance liquid chromatography - electrospray ionization ion trap and ultra high performance liquid chromatography - ion mobility - quadrupole time of flight mass spectrometry](https://mega.nz/#!9UxXGLyA!JSVJQOOEk…

Will Ceretropic ever carry N-PEP-12?

Replying to [deleted] · [deleted]

Yep, that's the reason we came out with P21. It hits CNTF like Cerebrolysin, but you don't have to worry about IM injections of large amounts of liquid extracted from pig's brains.

IT'S HERE!!!! P21

Replying to Kodarian · Is there a way to partition a study group? We would be willing to donate financially and possibly setup a request to gather funds from longecity or Reddit? P21 has cured many peo…

Setting up a proper study take a lot of funding and organization. It's not really possible to crowd fund something like this. You'd also run into legal hurdles, due to it not being an approved drug. Trying to do human drug trials on an unapproved compound is not a good idea. P21…

IT'S HERE!!!! P21

Replying to voyager256 · Thanks for response and raising standards within nootropic community. I don't know much about N-PEP-12 composition but I guess it's main MOA is similar to Cerebrolysin.

I believe they were trying to keep similar sequences to Cerebrolysin. So the MOA should be similar, if those sequences actually reach the brain via oral ROA. All I am seeing are effect studies, not pharmacokinetic studies.

IT'S HERE!!!! P21

Replying to Plasticperson32 · P21 is safe to take. Cerebrolysin uses Cyptic peptides. P21 is a segment of the THE peptide of focus.

I would not purport it as safe, since we don't have human studies behind it. I see no evidence to say it is unsafe, but that's not the same thing as safe. I tagged it as high risk because of how new it is.

IT'S HERE!!!! P21

Replying to voyager256 · OK. I've just ordered it. For some period M-D sold lyophilised P21 solution, but I remember you said it wasn't real, right? Regarding N-PEP-12 -there actually are a few studies, u…

Correct. The sequence was wrong. We attempted to use a lab in China to supply us P21 when our initial lab ran out of the amino acid we needed. This lab made us fake P21, with alanine instead of adamantane. So we rejected it. Then it seems they reached out to other vendors to offl…

IT'S HERE!!!! P21

Replying to voyager256 · It's great you finally have it back in stock. I'm going to order it and compare it's effects to Cerebrolysin and Cortexin. Are there any human studies of P21? As I understand it's …

Negative, no human studies. We are the only ones to ever really synthesize it in any real quantities. N-PEPT-12 is just an attempt to make an orally bioavailable version of the peptides from Cerebrolysin, but I do not see any evidence it is effective.

IT'S HERE!!!! P21

Replying to srubek · a peptide similar to cerebrolysin. increases cognitive performance. **edit::**~~check the [wiki](https://en.wikipedia.org/wiki/P21)~~*NEVERMIND* ... ~~underconstruction~~ edit:…

That's the wrong P21 srubek!

IT'S HERE!!!! P21

Replying to janowski_d · u/MisterYouAreSoDumb any chance you can describe P21 and Orexin-A and how they affect you? I know basics of them, but still info is quite spare. Is Orexin-a worth trying on top o…

Here's the thing, I want to avoid giving my own anecdotes for a bit, to prevent confirmation bias. I don't want people seeing how I react, then convincing themselves they react the same way. I want people to try it themselves, and assess things as objectively as they can. I will…

A new product, GHK-CU, is finally listed on Ceretropic.

Replying to baronjpetor · How do you feel/identify a histamine response? I combine NA Semax amidate with Cerebrolysin all the time and did not notice any adverse effect. BTW good to see that you're gonna c…

My airway closes, my eyes and skin get red, and I feel inflamed. I have a histamine disorder, though. So I am more susceptible to these things.

Semax and Selank Combination

Replying to NusAnileC · Thanks! I tried N-Acetyl Semax Amidate today. For Semax and Selank, do i take one after another? Like 2 sprays of Semax in each nostril, wait 3 mins, and then 2 sprays of Selank? A…

Yeah, that is what I do. Wait a minute or two between sprays, or just alternate nostrils. P21 is an activator of CNTF, or ciliary neurotrophic factor. That's the main mechanism for Cerebrolysin. Activation of CNTF promotes neurotransmitter synthesis and neurite outgrowth in certa…

Sublingual noopept with tablets?

Replying to 112358134 · Thank you for the invitation, Paul. It's pretty understandable that you don't like me. After all you were the one, who made people in the US familiar with Semax, Selank and some ot…

I think you are out of touch with reality. >So, be ready that it will be painful. Painful? What exactly are you implying here? You were the one that originally got offended by my tone. I am not even sure what you are on about. I don't care that you sell these things. I really don…

Anything similar to P21? Cortexin? Cerebrosylin?

Replying to OVE0 · You will find more information about cortexin in russian: https://translate.google.at/translate?hl=de&sl=ru&tl=en&u=http%3A%2F%2Fotzovik.com%2Freviews%2Fnootropniy_preparat_korteks…

You cannot order P21 from Chinese labs. There is one selling fake P21, though. We have exclusivity contracts with the lab that makes ours, and had to custom make one of the amino acids used in it. The stuff on the market right now is all fake.

N-Acetyl Semax, Cerebrolysin, P21, IDRA-21, PRL-8-53, NSI-189, or Fasoracetam + Coluracetam?

Post specific questions regarding what you should/plan on taking in /r/StackAdvice. /r/Nootropics is more for general nootropic discussions.

Anyone else interested in P21 nasal spray from Ceretropic?

Replying to roybo · Is there any research on p21? The search term "p21" gets over 31k hits on pubmed. The p21 page on wikipedia refers to some massive protein that has something to do with cancer. Ca…

You are looking at the wrong P21. There are two compounds commonly referred to as P21.

Closest RC or Pep to GH*?

Replying to arlowf · :( So... I'm not going after recreational use here. I'm going after "Perfect form and I sleep like a baby". If you have ever tried G in a non-recreational fashion, you'd understand…

I understand. I have never personally tried GHB. However, my late partner had insomnia, and said GHB worked fantastically for getting to sleep. You comments about getting drunk made me think you wanted recreational effects. If you are looking for sleep, I have actually found the…