Comment · Mon, February 9, 2026 · Natrium Health & Nootropics Depot
The story behind the FDA raid of Nootropics Depot
What they were answering
DoctorBoneMarrow · 1 points
Can you share why you think tianeptine is such a good antidepressant (mechanistically speaking) when used correctly?
Do you think it might have an interesting synergy with Cognance?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
When we first brought it out, the SSRE effects were interesting, as no other antidepressants had that effect. When we learned it had opioid affinities, that wasn't a bad thing at first. Your body has endogenous compounds that bind to the opioid receptors called endorphins, enkephalins, dynorphins, and endomorphins. So even the opioid affinities I still find interesting. Sure, it means you can abuse it, but that can be said of a lot of things that make you feel better. Tianeptine also modulates glutamate, which is a useful mechanism in depression. Then it also increases BDNF, but it does so without the strange side effects that SSRIs have. I was prescribed multiple SSRIs when I went through my depression, and it only made things worse. It just made the nothingness feeling stronger. People say that all the time, that SSRIs make them feel like a robot. This is also why they have a warning that they can lead to increased suicidal ideation. Tianeptine doesn't have that. I still maintain it is a very cool antidepressant that would help a lot of people if it was approved. The demonization of it, because assholes chose to sell it in gas stations as shots to get you high, is just misguided.