Anybody Have a Clue What Ebelin Lactone’s 5-HT2A binding affinity is?

Comment · Sat, December 3, 2022 · 27 pts

The affinities are: M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) in a statistical model. We still need to run receptor binding assays to assess the real world numbers, though. We will be doing that.

Comment · Sat, December 3, 2022 · 15 pts

It's not a simple thing, as what makes a "good" (low, moderate, high) binding affinity differs between the various receptors and the actual function of the ligand. If it is a competitive agonist, then the binding affinit

Comment · Sat, December 3, 2022 · 20 pts

Correct. The binding affinity to M1 is a lot higher than 5-HT2A. Some people might even be more excited about the M1 effects anyway. They are also PAMs, so it is different than direct agonists. Frankly, we don't want it

Comment · Sat, December 3, 2022 · 12 pts

Since the link between choline and depressive symptoms is not fully understood, that's hard to say. I will say that I get depressed from too much choline, but I have been using Cognance for the past year without issue. M

Comment · Sat, December 3, 2022 · 7 pts

No

Comment · Sun, December 4, 2022 · 10 pts

Have you been checked for rabies? I kid! Thanks for the report. I will keep an eye out to see if other people report the same thing.

Comment · Mon, December 5, 2022 · 3 pts

I think the thought was that we didn't want to get criticized for trying to make it seem like there were more doses in a jar by "artificially" lowering the dose. Whether that is valid or not is up for debate. It's also s