Comment · Fri, November 25, 2022 · ND Owner
What they were answering
jsmith50 · 1 points
ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors
Does this mean it is a PAM and an agonist?
u/MisterYouAreSoDumb · ND Owner
No, it is referring to its affinity as a PAM in this quote.
Comment · Thu, November 24, 2022 · 3 pts
No, it's our lab director Jay in the video with Emiel. He was excited to get to drive the Delorean!
Comment · Thu, November 24, 2022 · 9 pts
Hahahahahaha! That's great!
Comment · Thu, November 24, 2022 · 3 pts
In what way don't you respond well?
Comment · Thu, November 24, 2022 · 10 pts
You don't need to wake up in the middle of the night. We will be fine on stock. To sell out, we would have to have such an ungodly amount of traffic, it would likely break the site. We've prepared for this. This ain't ou
Comment · Thu, November 24, 2022 · 15 pts
There is a compound that gets created in small amounts when you take bacopa called ebelin lactone. This compound is a result of a complex metabolism that happens in the body in a limited fashion. We developed a patented
Comment · Thu, November 24, 2022 · 18 pts
No, that was a big part of doing this. Ebelin lactone does not have acetylcholinesterase inhibiton effects, and it actually slightly stimulating instead of calming/demotivating. Cognance feels very different than any oth
Comment · Thu, November 24, 2022 · 4 pts
I have not. It's hard to say, as tolerance is a poorly understood concept to many things. There's no replacement for reported effects from a large sample size of people, so we will likely learn more as larger amounts of
Comment · Thu, November 24, 2022 · 6 pts
It very well could be! Ebelin lactone will get created in small amounts when taking other bacopa extracts, but that process is extremely variable and uncontrolled. This one does not cause any of that foggy/groggy feeling
Comment · Thu, November 24, 2022 · 6 pts
This extract absolutely still retains the memory effects, and enhances them. Both the 5-HT2A and M1 receptor effects are very targeted for memory. [Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal
Comment · Thu, November 24, 2022 · 3 pts
Very interesting! I have been mixing in some Magtein with my Clarimag doses, and I have been noticing more hair growth as well!
Comment · Thu, November 24, 2022 · 6 pts
Every Monday we have a new products call with the whole team. Then usually every other Thursday we have more in-depth in-person meetings regarding some of our R&D projects. The depth and breadth of the things we discuss
Comment · Thu, November 24, 2022 · 6 pts
We definitely have more dopamine-focused things in store, along with some really cool stacks on that side of things!
Comment · Thu, November 24, 2022 · 5 pts
Good catch! Fixed
Comment · Thu, November 24, 2022 · 5 pts
I can't really discuss prescription drugs. However, I have combined Cognance with other natural dopamine releasers, and the synergy was really nice.
Comment · Thu, November 24, 2022 · 13 pts
LOL, not removing the Oxford comma, but I will put it in the right place! Oxford comma till death! I think what happened was /u/Pretty-Chill is from the Netherlands, and doesn't use an Oxford comma. I always do, so when
Comment · Thu, November 24, 2022 · 14 pts
I would suggest starting at our recommended dosage. That being said, I have taken 200-300mg of it multiple times before, and it gets a lot more interesting... This is especially true when combined with a dopaminergic sup
Comment · Thu, November 24, 2022 · 25 pts
I have paired it with kava a few times. Our kava is really focused on pain/muscle relaxation, so they are fine together. However, I think a more heady kava would synergize better. Luckily our bank has FINALLY agreed to l
Comment · Fri, November 25, 2022 · 16 pts
Our bank has to approve all our products before we sell them now. It's an agreement we made with them years ago to ensure we always have steady card processing. In the US, banks are allowed to drop your business anytime
Comment · Fri, November 25, 2022 · 7 pts
5-HT2A and 5-HT2B are different receptors, so no issue there. Also, the heart issues are for full agonists of the 5-HT2B receptor. Ebelin lactone is a positive allosteric modulator of the 5-HT2A receptor.
Comment · Fri, November 25, 2022 · 3 pts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428790/
Comment · Fri, November 25, 2022 · 3 pts
Cognance is better for the morning/mid day, as it is slightly stimulating. I wouldn't take it before bed. However, my sleep has been very good on it when I space the dosing out from the evening.
Comment · Fri, November 25, 2022 · 6 pts
I have not noticed much, if any, tolerance to the normal 100mg dose. I have cycled off and back on a few times without any issues.
Comment · Fri, November 25, 2022 · 3 pts
https://imgur.com/a/xdMeqnQ
Comment · Fri, November 25, 2022 · 4 pts
Yeah, we will get crypto back as an option at some point. The big issue is integrations. We built a custom one for Coinpayments, and worked with their development team to have them do a full integration with Bigcommerce
Comment · Fri, November 25, 2022 · 4 pts
That's a more complex question that will take more research to answer for sure. I talked about it a bit in this comment. https://www.reddit.com/r/NootropicsDepot/comments/yzlii8/where_were_going_we_dont_need_roads/ix91h
Comment · Fri, November 25, 2022 · 12 pts
I'd say 6-8 hours, but the effects build over time. I take it daily. That seems to be best for this one. I have cycled off a few times with no issues. I'd say just stick to your normal cycle regimen, and go back to basel
Comment · Fri, November 25, 2022 · 3 pts
Yes, the M1 receptors are a big part of its effects. Both 5-HT2A and M1 seem to work synergistically for mood and memory.
Comment · Fri, November 25, 2022 · 1 pts
Yeah, it's hard to build up inventory for a product when we don't have the raws. We are at the mercy of US customs sometimes.
Comment · Fri, November 25, 2022 · 3 pts
I hope it is popular, so we can fund interesting studies on it! Pushing the science forward is always the most rewarding part of all this.
Comment · Fri, November 25, 2022 · 2 pts
Really? I just tried it, and it goes to the staff favorites page. Are you on mobile or desktop? Stealth edit: That was it. Desktop link was correct. Mobile link was wrong. It's fixed now.
Comment · Fri, November 25, 2022 · 3 pts
I have been using it every day, cycling off every couple months or so. However, I am curious to see how people respond to shorter cycles.
Comment · Fri, November 25, 2022 · 3 pts
That's a tough one to sat for sure. My theory is that the depressive symptoms some people get from serotonergic things like that is a result of a drop in dopamine, due to a saturation of the aromatic L-amino acid decarbo
Comment · Sat, November 26, 2022 · 3 pts
It only released at midnight last night, so nobody would have gotten theirs yet.
Comment · Sat, November 26, 2022 · 3 pts
I can't talk about prescription drugs or diseases, due to FDA guidelines. I have to be careful about things.
Comment · Sun, November 27, 2022 · 10 pts
It's been years of us honing our facility and systems to get efficient. I am super proud of my warehouse! I actually went in to the office around 7:30pm yesterday because I was out of L-theanine, and I wanted to grab a b
Comment · Sun, November 27, 2022 · 2 pts
No issues there. I have combined it with lemon balm and other GABAergic compounds multiple times, and there is synergy there if you want the effects a bit more calm.
Comment · Sun, November 27, 2022 · 3 pts
Some people like the calming/sedating effects that a regular bacopa gives. Many people take it in the evening before bed. Cognance would not be a replacement for that.
Comment · Mon, November 28, 2022 · 7 pts
It's one reason I cringe when I see people online say we have expensive shipping. It's the best value on the planet for what you get, in my opinion. You saw that customer post yesterday where he got his order the very ne
Comment · Mon, November 28, 2022 · 3 pts
I have a few times. It makes things even more stimulating, so watch out if you have other AMPK activating things in your stack.
Okay, so I am finally getting around to make a post about the results of some of the lab testing we have been doing. I've had the results for a bit, but I've been holding off on officially releasing them because frankly
Replying to lewanay · Their top pick is Youtheory over ND: “Like Youtheory, Nootropics Depot also contains PrimaVie, but it is more expensive: A serving of Nootropics offering 250 mg of extract costs 6…
The youTheory capsules are 250mg like ours. They just tell you to take 2 for a dose. That's the dosing games brands play to trick people into thinking they are cheaper. If they wanted a dose to be 500mg, they should have
Replying to TTran1485 · I would like to thank Nootropics Depot for never releasing/forever delaying the Bacopa tickler, since it has motivated me to grow my own mushrooms. All the thanks
We're just edging you. Juuuuuust a little bit more...
I actually just wrote most of this in [a comment](https://www.reddit.com/r/Nootropics/comments/djmsh2/how_widespread_are_fake_supplements/f51olnp/) on /r/Nootropics, but I figured I would make a post here for everyone. W
Replying to alpacasb4llamas · Once every single form of glutathione possible has been achieved.
**Aragorn:** Gentlemen! We do not stop 'til we've released the new bacopa! **Pippin:** But what about glutathione? **Aragorn:** You've already had glutathione. **Pippin:** We've had one, yes. But what about S-Acetyl G
Replying to ROTHUM2 · Everyone seems to love this stuff. But it’s just like any other bacopa for me — makes me tired, feel off.
Tired is interesting, as the biggest side effect we have had reported so far is insomnia if taken too close to bedtime. However, nothing surprises me anymore. I know someone that gets zero effects from IV morphine. Every