Comment · Fri, April 22, 2022 · ND Owner

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NDSocialMedia · 44 points

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What they were answering

Friedrich_Ux · 3 points

Awesome, I have an MAOA polymorphism and any substances that raise 5HT like Bacopa or Magnolia make me feel dreadfully lazy and anhedonic, would love an extract that is primarily DA/NE and and sigma-1.

u/MisterYouAreSoDumb · ND Owner

I personally gravitate away from the 5-HT effects as well. This is why we are still making my "perfect" saffron. I wanted to release this one first, though. It's more what most people are looking for in a saffron.

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Commentr/NootropicsDepotJan 9, 2021Nootropics DepotND Owner

MisterYouAreSoDumb, what is your current stack and why?

My base stack stays pretty consistent, but I have modified some things. * Reacta-C * Vitamin D3/K2 (not released yet) * CoQSol-CF * Our Yeast Extract * Microzinc * Berberine/Silymarin * Our EGCG tablets * Our (-)-epicat

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Commentr/NootropicsDepotApr 23, 2022Nootropics DepotND Owner

Is your Saffron mislabeled or is the Spec sheet wrong?

Replying to MrNotSoSerious · Is this the long-anticipated md supp that you had been teasing for over a year (or is that one still supposed to be made with bacopa) ?

The saffron? No, this is a good balanced saffron extract for mood and appetite suppression. It doesn't hit the same systems like our patented bacopa. I am pushing to get that out in the next few months, though. The paten

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Commentr/NootropicsDepotMay 2, 2024Enforcement & pleaND Owner

⚠️ NEW PRODUCT RELEASES ARE COMING 5/9/24 | Two Mystery Products, L-Tryptophan Capsules, & Supercritical CO2 Cistanche Capsules⚠️

Replying to TheGermanGuy21 · Thanks for the reply. You mention sedation, but any idea why Cistanche might make some people feel dysphoric/depressed on it, even the next day? Reminded me of how I reacted to Agm…

Yeah, I think 5-HT1B is the most likely mechanism behind that effect you are getting. That receptor is a current target of interest in depression research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919989/ Think of

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Commentr/NootropicsDepotSep 15, 2023Enforcement & pleaND Owner

🎙️Discovering Bacopa Q&A | Post Your Questions From Our Latest Podcast Episode!🎧

Replying to chris106 · Erinamax has serotonergic effects too? Or do you mean norepinephrine from Erinamax complimenting the serotonergic effects of the other two?

No, it has BDNF and NGF effects, and yes, the NE effects should compliment the serotonin effects from the saffron/Cognance. However, the color improvement effects I have yet to figure out the mechanism for. It's somethin

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Commentr/NootropicsDepotDec 1, 2024Enforcement & pleaND Owner

Cognance Bacopa

Replying to Lazlo25 · Oh really, dopimanergics? Is there any theoretical explanation for that or is it just observation? What do you think about combining it with your high potency saffron extract?

[Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder](https://pmc.ncbi.nlm.nih.gov/articles/PMC4279075/) [Anatomical relationships between serotonin 5-HT2A

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Commentr/NootropicsDepotMay 5, 2022Nootropics DepotND Owner

Anyone try the saffron yet?

Replying to jarrellt67 · Do you see any issues combining saffron with your bacopa extract? I love the increase in mood from saffron but the stimulation seems to be increasing more and more each day. Your…

So you are getting too much stimulation from the saffron? In that case, combining with bacopa could be a good combo. I don't see any reason why there would be a problem stacking them. Maybe take a little L-tyrosine with

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