Comment · Sun, December 1, 2024 · ND Owner

Cognance Bacopa

Original post in this thread

Lazlo25 · 8 points

I'm finally buying Cognance Bacopa as part of my black friday shopping.

Since it is a PAM of 5HT2A, does that mean it should make Serotonergics like SSRIS and espeically psychadelics stronger?

Any insight or experiences would be greatly appreciated!
u/Misteryouaresodumb I'm lookin at you :0

What they were answering

Lazlo25 · 3 points

Oh really, dopimanergics? Is there any theoretical explanation for that or is it just observation?
What do you think about combining it with your high potency saffron extract?

u/MisterYouAreSoDumb · ND Owner

Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder

Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain

5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum

The 5-HT2A receptor is actually implicated in modulating dopamine. Also, the M1 affinities of ebelin lactone affect dopamine, too.

Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens

I combine our saffron and Cognance daily. I really like the effects. Our Berbelean stack contains saffron, and that's what I have moved to in the mornings. The berberine in it helps with mood and cognition as well, through multiple pathways.

Pharmacological effects of berberine on mood disorders

Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65

I think the combo of Berbelean, Cognance, Erimamax, and Sabroxy is a really nice one!

Other MYASD lines in this thread

Comment · Sat, November 30, 2024 · 6 pts
It depends on the relative binding affinities of the 5-HT2A agonist you are combining it with, but yes. I have noticed that Cognance potentiates other seritonergics. What I have really found synergizes with it are dopami

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Replying to psychopythonmetrist · Awesome! Very excited to try it out. Also interested in the other saffron extracts being developed. You and your team are absolutely killing it this year. Really looking forward …

Glad you are liking things! We've been working hard on all these new products. We have a lot of cool stuff still ahead!

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Commentr/NootropicsDepotApr 23, 2022Nootropics DepotND Owner

Is your Saffron mislabeled or is the Spec sheet wrong?

Replying to MrNotSoSerious · Is this the long-anticipated md supp that you had been teasing for over a year (or is that one still supposed to be made with bacopa) ?

The saffron? No, this is a good balanced saffron extract for mood and appetite suppression. It doesn't hit the same systems like our patented bacopa. I am pushing to get that out in the next few months, though. The paten

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Replying to chris106 · Erinamax has serotonergic effects too? Or do you mean norepinephrine from Erinamax complimenting the serotonergic effects of the other two?

No, it has BDNF and NGF effects, and yes, the NE effects should compliment the serotonin effects from the saffron/Cognance. However, the color improvement effects I have yet to figure out the mechanism for. It's somethin

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Anyone try the saffron yet?

Replying to jarrellt67 · Do you see any issues combining saffron with your bacopa extract? I love the increase in mood from saffron but the stimulation seems to be increasing more and more each day. Your…

So you are getting too much stimulation from the saffron? In that case, combining with bacopa could be a good combo. I don't see any reason why there would be a problem stacking them. Maybe take a little L-tyrosine with

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