Comment · Thu, May 2, 2024 · ND Owner
⚠️ NEW PRODUCT RELEASES ARE COMING 5/9/24 | Two Mystery Products, L-Tryptophan Capsules, & Supercritical CO2 Cistanche Capsules⚠️
Original post in this thread
NDSocialMedia · 56 points
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Mystery Product #1 Hints
1. The plant family that this herb comes from, has about 1600 species in it. A large amount of these species are commonly used as spices or bioactive herbs.
2. This herb is from a country that was featured in a film in which the actors could have probably benefited from some alcohol defense!
Mystery Product #2 Hints
1. This stack has been developed to modulate a sensation that early philosophers thought was merely an emotion. A group of philosophers even thought that this sensation was produced predominantly by the heart, but that has been disproven.
2. Contrary to other stacks designed for this purpose, our stack focuses a lot of attention on the GABAergic system.
L-Tryptophan Capsules
* Crucial for serotonin synthesis
* Converts to 5-HTP in the body
* Helps regulate mood
* Great to take with dopaminergic supplements
Supercritical Cistanche Capsules
* Potent standalone extract from…
What they were answering
TheGermanGuy21 · 2 points
Thanks for the reply. You mention sedation, but any idea why Cistanche might make some people feel dysphoric/depressed on it, even the next day? Reminded me of how I reacted to Agmatine, but maybe it had to do with the upregulation of 5-HT1B you mentioned. Now that I think about it, maybe it did feel akin to Bacopa, which affects serotonin as well, but it's probably way more complicated than just "Serotonin", cause e.g. ND's Saffron is awesome and extremely stimulating.
Even though it may be unpredictable how different people's biochemistry react to it, do we know how the Supercritical Extract differs in its MOA?
u/MisterYouAreSoDumb · ND Owner
Yeah, I think 5-HT1B is the most likely mechanism behind that effect you are getting. That receptor is a current target of interest in depression research.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919989/
Think of our Cistanche products as a sliding scale.
* Non-Extracted Cistanche: 5% echinacoside | 1% verbascoside
* Original Cistanche Extract: 50% echinacoside | 10% verbascoside
* Supercritical Cistanche: 20% echinacoside | 20% verbascoside
It's the difference in ratios of these actives that alters the effects. If 5-HT2B is really the thing causing your side effects, the supercritical CO2 extract would actually be worse for you, due to the higher verbascoside. However, the mechanisms are always much more complex than they seem on the surface. You could very well have a much more positive effect with the supercritical extract. Verbascoside seems to be more effective at up-regulating the HPG axis than echinacoside.
https://www.tandfonline.com/doi/full/10.1080/13880209.2021.1933085