Comment · Thu, November 26, 2020 · ND Owner
N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.
Original post in this thread
squirtking33 · 28 points
I suffer with some awful persistent infections that, when under stress, create an opportunistic environment for latent bacterial, viral and fungal infections to take a hold. Borreliosis has, however, been the worst infection I’ve had to fight. No, I’m not talking about Lyme Disease, which is a fraudulent case definition of a single bad knee, falsified by the likes of Wormser, Weinstein, Halaprin, Klmepner, Steere, Shapiro, etc., however, I won't get into that whole ordeal. In any case, neuroorreliosis is known to cause increased glutamate, Ammonia, in some cases; and especially Quinolinic Acid in the brain, a potent excitatory neurotoxin. Nothing had worked for me except one thing and that was the antibiotic ceftriaxone (Rocephin) even if it may not kill even half of viable spirochetes in vitro.
Ceftriaxone was amazing for my pain, brain sparks, probably due to QUIN; verbal fluidity, brain fog, headaches, anxiety and eradicated depression. No other nootropic or drug, had cleared my brain of noise and anxiety better than ceftriaxone, now I’m sure it was partly to do with it helping to clear out neuroborreliosis but its underlying mechanisms of actions are interesting. Plu,s I h…
What they were answering
squirtking33 · 5 points
So, I was researching some more and it I think the best stack for anxiety and depression would be a herb or several herbal extracts and micronutrients that work on the translational control of glial Glutamate Transporter
EAAT2 Expression, also taken with something from time to time that increases EAAT2 Glu Transporter expression liek Rocephin does, but not Rocephin, obviously, and an IDO enzyme modulator like Lemon balm to combat levels of QUIN and increase levels of Serotonin down the split of the L-tryptophan pathway or Passionflower extract; but Passionflower and Lemon balm both have harmine in them, don't know what Passionflower does to IDO and of course some sort of nmda modulator.
Of course, the question of bioavailability is of concern and dosage, etc.
u/MisterYouAreSoDumb · ND Owner
It's going to probably be a combination of herbs. Not sure we can get one to hit everything strongly. I do think we can get there with a combo of 3-4 herbs specifically made for it, though.