Comment · Tue, November 24, 2020 · ND Owner
N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.
Original post in this thread
squirtking33 · 28 points
I suffer with some awful persistent infections that, when under stress, create an opportunistic environment for latent bacterial, viral and fungal infections to take a hold. Borreliosis has, however, been the worst infection I’ve had to fight. No, I’m not talking about Lyme Disease, which is a fraudulent case definition of a single bad knee, falsified by the likes of Wormser, Weinstein, Halaprin, Klmepner, Steere, Shapiro, etc., however, I won't get into that whole ordeal. In any case, neuroorreliosis is known to cause increased glutamate, Ammonia, in some cases; and especially Quinolinic Acid in the brain, a potent excitatory neurotoxin. Nothing had worked for me except one thing and that was the antibiotic ceftriaxone (Rocephin) even if it may not kill even half of viable spirochetes in vitro.
Ceftriaxone was amazing for my pain, brain sparks, probably due to QUIN; verbal fluidity, brain fog, headaches, anxiety and eradicated depression. No other nootropic or drug, had cleared my brain of noise and anxiety better than ceftriaxone, now I’m sure it was partly to do with it helping to clear out neuroborreliosis but its underlying mechanisms of actions are interesting. Plu,s I h…
What they were answering
clementehling · 2 points
Palmitoylethanolamide (also through PPAR-gamma)
Hesperidin do that also
https://pubmed.ncbi.nlm.nih.gov/26342684/
Wich one is the best ?
u/MisterYouAreSoDumb · ND Owner
Ohh wow! Yeah, hesperidin as well. As to which is better, we are in somewhat uncharted territories here. There is good evidence for the mood-boosting effects of hesperidin, though.
Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence
In fact, many flavones are being looked at as potentials.
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases.
It looks like EGCG has a similar effect, too.
Epigallocatechin‐3‐gallate protects motor neurons and regulates glutamate level
EGCG protects HT-22 cells against glutamate-induced oxidative stress
7,8-DHF is also listed as one that has a bunch of potential for many neurodegenerative issues.