Comment · Tue, November 24, 2020 · ND Owner
N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.
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squirtking33 · 28 points
I suffer with some awful persistent infections that, when under stress, create an opportunistic environment for latent bacterial, viral and fungal infections to take a hold. Borreliosis has, however, been the worst infection I’ve had to fight. No, I’m not talking about Lyme Disease, which is a fraudulent case definition of a single bad knee, falsified by the likes of Wormser, Weinstein, Halaprin, Klmepner, Steere, Shapiro, etc., however, I won't get into that whole ordeal. In any case, neuroorreliosis is known to cause increased glutamate, Ammonia, in some cases; and especially Quinolinic Acid in the brain, a potent excitatory neurotoxin. Nothing had worked for me except one thing and that was the antibiotic ceftriaxone (Rocephin) even if it may not kill even half of viable spirochetes in vitro.
Ceftriaxone was amazing for my pain, brain sparks, probably due to QUIN; verbal fluidity, brain fog, headaches, anxiety and eradicated depression. No other nootropic or drug, had cleared my brain of noise and anxiety better than ceftriaxone, now I’m sure it was partly to do with it helping to clear out neuroborreliosis but its underlying mechanisms of actions are interesting. Plu,s I h…
What they were answering
squirtking33 · 2 points
I cannot, however, seem to find anything as potent as the B-lactem antibiotic Rocephin on increasing glutamate transporter EAAT2 expression. Harmine, which I beleive is a psychedelic is fairly potent, not sure if it has any serious side effects. Lemon balm has harmine but so little it won't do much.
I have L-Carnosine, use to use it a lot but it seemed, this could just be a coincidence, but it seemed to increase an overgrowth of melanocytes.
Never tried magnolia bark, but I have read other studies that the PPAR-gamma pathway can indirectly effect Quinolinic acid and Glutamate concentrations in the brain.
Nigella sativa, good for NK cells, didn't do anything for anxiety. The effect of Rocephin on clearing glutamate was night and day. I wish I could find some potent herbal extract that worked to increase the expression of EAAT2 which encompasses 90% of all EAAT's in the brain.
u/MisterYouAreSoDumb · ND Owner
Perhaps working on a higher harmine natural extract would be ideal. It's not something that is commonly standardized, but it could be.