N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.

Comment · Mon, November 23, 2020 · 12 pts

You just might be on to something here! I am going to have to do some more research and discuss with the team. However, it could definitely be a novel mechanism to target. Some things off the top of my head to try would

Comment · Tue, November 24, 2020 · 3 pts

Perhaps working on a higher harmine natural extract would be ideal. It's not something that is commonly standardized, but it could be.

Comment · Tue, November 24, 2020 · 2 pts

Ohh wow! Yeah, hesperidin as well. As to which is better, we are in somewhat uncharted territories here. There is good evidence for the mood-boosting effects of hesperidin, though. [The Antidepressant-Like Effects of He

Comment · Tue, November 24, 2020 · 2 pts

Yes, it is legal. DMT is not, but harmine is. You just often seen harmine in combo with DMT, like in Ayahuasca. However, we can get harmine from other plants like passionflower. In fact, it was something we were already

Comment · Tue, November 24, 2020 · 3 pts

Glutamate is certainly PART of the culprit. I think there is a genetic portion of long-term tolerance as well that is much less understood. Look into IEG expression, or immediate early genes. This would explain the seemi

Comment · Thu, November 26, 2020 · 3 pts

We already have something in the works. There are multiple species of passionflower, and multiple cultivars of those species. It's funny you made this post, since we literally just started working on this like 2 weeks ag

Comment · Thu, November 26, 2020 · 3 pts

It's going to probably be a combination of herbs. Not sure we can get one to hit everything strongly. I do think we can get there with a combo of 3-4 herbs specifically made for it, though.

Comment · Sun, November 29, 2020 · 2 pts

I don't really have a proven answer, unfortunately. We are still learning about IEG expression. Perhaps this EAAT2 targeting will prove to be a workable strategy. We are certainly missing some big piece of the picture wi

Comment · Sun, November 29, 2020 · 1 pts

They do, and some people have noticed improvements in tolerance to certain things with piracetam/noopept use. Those generally are not permanent, though. So it's more complex than just lowering/protecting against glutamat

Comment · Sat, January 9, 2021 · 2 pts

It's only been a month. R&D takes a lot more time than that. I wouldn't expect meaningful movement on something till later this year. What all have you tried to address it? Have you tried things like L-theanine and lemo

Comment · Tue, January 12, 2021 · 2 pts

Let me know how you react to the magnolia bark and lemon balm. You might need to stack a few things together to get the strength in effects you are looking for, too.

Comment · Thu, February 11, 2021 · 2 pts

No, because of the rate-limiting enzymes in between. You want to overwhelm your carnosinase enzyme to get your plasma levels up enough to make a difference. That won't happen if you take beta-alanine. The enzymes will no

Comment · Thu, February 11, 2021 · 3 pts

So your body has rate-limiting enzymes in place to control how much of various things get made, right? The two I talk about a lot are tryptophan hydroxylase (TPH) and aromatic L-amino acid decarboxylase (AAAD). TPH is wh

Comment · Thu, February 11, 2021 · 2 pts

It's the same reason why most people benefit from taking phenylalanine, but people with phenylketonuria need to be careful with it. Balance is key. We can tip that balance a bit one way and we see benefits. Tip too far f

Comment · Thu, February 11, 2021 · 2 pts

Yeah, NAC will allow you to take a lower dose. Half is our best estimate.

Comment · Fri, April 2, 2021 · 2 pts

You can certainly start with carnosine and magnolia bark to see how you respond. It's good slowly adding things in anyway, rather than jumping straight into a larger stack. That way you can assess how each one is affecti