Comment · Thu, February 11, 2021 · ND Owner
N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.
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squirtking33 · 28 points
I suffer with some awful persistent infections that, when under stress, create an opportunistic environment for latent bacterial, viral and fungal infections to take a hold. Borreliosis has, however, been the worst infection I’ve had to fight. No, I’m not talking about Lyme Disease, which is a fraudulent case definition of a single bad knee, falsified by the likes of Wormser, Weinstein, Halaprin, Klmepner, Steere, Shapiro, etc., however, I won't get into that whole ordeal. In any case, neuroorreliosis is known to cause increased glutamate, Ammonia, in some cases; and especially Quinolinic Acid in the brain, a potent excitatory neurotoxin. Nothing had worked for me except one thing and that was the antibiotic ceftriaxone (Rocephin) even if it may not kill even half of viable spirochetes in vitro.
Ceftriaxone was amazing for my pain, brain sparks, probably due to QUIN; verbal fluidity, brain fog, headaches, anxiety and eradicated depression. No other nootropic or drug, had cleared my brain of noise and anxiety better than ceftriaxone, now I’m sure it was partly to do with it helping to clear out neuroborreliosis but its underlying mechanisms of actions are interesting. Plu,s I h…
What they were answering
Aldarund · 1 points
\> Carnosinemia
So why would overwhelming carnosinase produce positive effects if when people have low carnosinase at start as with carnosinemia they get bad effects, not a good ones.
u/MisterYouAreSoDumb · ND Owner
It's the same reason why most people benefit from taking phenylalanine, but people with phenylketonuria need to be careful with it. Balance is key. We can tip that balance a bit one way and we see benefits. Tip too far for too long and you can see downsides. Taking carnosine will help push plasma levels up for a bit, but they will then fall again as carnosinase metabolizes it. Take out the ability to remove carnosine from plasma altogether, and its a different story. Some dopamine is good. Too much dopamine is bad. Some cholesterol is good. Too much is bad. Same theme. You want to tip the scales slightly in the positive direction, but not too far to cause issues.