Comment · Sat, November 7, 2020 · ND Owner
My experience with ND’s NMN
Original post in this thread
tazmanianalbanian · 11 points
I bought nootropics depot nmn
capsules excited to try them. I’ve had great experience with NMN before, using powder for a few months.
Unfortunately my body is unable to break through the thick coating of the pills and they pass right through me, out in my stool. This has happened each time I take them, I’ve decided I will likely switch back to the powder.
Is anyone else facing this issue? Thanks
What they were answering
12ealdeal · 2 points
Noted.
Though I haven't found other pills, some of which are also enteric coated (wobenzym, proteolytic enzymes) in my stool. How do I explain that?
This may not reflect reality, but I left 1 NMN and 1 green tea extract pill in a glass of pH neutral water over night.....it did not dissolve.
I left them then in a glass with some baking soda.....it still did not dissolve.
I understand I should investigate further on my end. But perhaps if other people in this thread are communicating the same problem, maybe, just maybe it's a issue with the company doing the coating?
You guys at ND have all the infrastructure in terms of instrumentation. Is the quality of the enteric coating something you ever test or run through the gauntlet? Seeing as you do outsource that process to a different company.
Again, not my intention to be problematic, there is an element of buyers remorse as I have spent hundreds of dollars on your NMN alone (outside of the thousands I spend on other ND supplements). I will look into my own health for answers to this, but I feel it's also something to heed and consider given the contents of this thread.
u/MisterYouAreSoDumb · ND Owner
Though I haven't found other pills, some of which are also enteric coated (wobenzym, proteolytic enzymes) in my stool. How do I explain that?
Maybe it is the specific coating we use? It's methylcellulose from Dupont.
This may not reflect reality, but I left 1 NMN and 1 green tea extract pill in a glass of pH neutral water over night.....it did not dissolve.
I left them then in a glass with some baking soda.....it still did not dissolve.
Neutral water is not the same as a gastric buffer/intestinal buffer. USP has a simulated intestinal fluid that consists of potassium dihydrogen phosphate, sodium hydroxide, and deionized water. That is what would be used as a test after passing through a gastric buffer with a lower pH.
I understand I should investigate further on my end. But perhaps if other people in this thread are communicating the same problem, maybe, just maybe it's a issue with the company doing the coating?
You guys at ND have all the infrastructure in terms of instrumentation. Is the quality of the enteric coating something you ever test or run through the gauntlet? Seeing as you do outsource that process to a different company.
Again, not my intention to be problematic, there is an element of buyers remorse as I have spent hundreds of dollars on your NMN alone (outside of the thousands I spend on other ND supplements). I will look into my own health for answers to this, but I feel it's also something to heed and consider given the contents of this thread.
No, you are right. I will do some more lab testing on our end to make sure. I recently bought us a really nice Distek automated disintegration tester. So we can absolutely run some testing on this to get lab data on it.
You can see it here: https://www.distekinc.com/products/sensir-3200/