NMN, Niacin, NAD +, and Addiction

Comment · Thu, September 24, 2020 · 4 pts

Niacin is associated with side effects like flushing with high acute doses, and associated with liver toxicity in extended release forms. So it is not idea for increasing NAD+. https://pubmed.ncbi.nlm.nih.gov/12901025/

Comment · Fri, September 25, 2020 · 2 pts

I think enteric coated NMN with a CD38 inhibitor like hesperidin is the absolute best way to increase NAD+.

Comment · Fri, September 25, 2020 · 3 pts

I am not saying niacin is bad. It's just not nearly as effective as NMN. If you taken our enteric coated NMN with a CD38 inhibitor like ~~hesperidin~~ quercetin, you are going to increase NAD+ way more than any dose of n

Comment · Fri, September 25, 2020 · 4 pts

Yes, flushing is a side effect for many people. Is this really a surprise? Not everyone is pumping iron at the gym. The effect is also not the same. He also asked why someone might use NMN instead of high dose niacin. I

Comment · Fri, September 25, 2020 · 3 pts

What evidence are they using as a justification for that theory? It appears that NMN and NR positively affect inflammatory markers. https://pubmed.ncbi.nlm.nih.gov/21901281/ https://www.ncbi.nlm.nih.gov/pmc/articles/PM

Comment · Sat, September 26, 2020 · 8 pts

With niacin you have 3 rate-limiting enzymes controlling the amount of NAD+ created: NARPT, NMNAT, and NADSYN1. With NMN you only have one: NMNAT. It only stands to reason that you can increase NAD+ faster and to a highe

Comment · Sat, September 26, 2020 · 1 pts

Yeah, that is a good stack. If you are looking for fat burning, OptimALA and our EGCG tablets would be good to add in as well.

Comment · Sat, September 26, 2020 · 3 pts

My pleasure! Here is another way to visualize it. What do you think will raise dopamine levels higher/quicker, L-phenylalanine or L-DOPA? L-phenylalanine has three rate-limiting enzymatic steps between it and dopamine. L

Comment · Sat, September 26, 2020 · 2 pts

That's interesting. I know that some people's microbiome can metabolize tea catechins differently than others. Maybe yours are doing that, and creating compounds that are causing you to feel sick?

Comment · Mon, September 28, 2020 · 2 pts

Interesting... I am going to have to research more to have an informed position on it. I don't want to immediately write it off because I suppose the possibility is there. I am actually cycling off NMN at the moment, so

Comment · Mon, September 28, 2020 · 4 pts

Our EGCG tablets are enteric coated, too. So they avoid the stomach and get the tea catechins right to the small intestine. I would be curious to see how that affects how you respond. Here is the study on tea catachins

Comment · Tue, September 29, 2020 · 1 pts

Yeah, it is definitely an interesting theory. I have been a bit more inflamed lately, but I have been moving houses and lifting a lot of stuff. So it is hard to say what is having the most effect there.

Comment · Mon, October 5, 2020 · 6 pts

God dammit, I mistyped. QUERCETIN is what I meant. We just recently added both quercetin and hesperidin, and my dumb brain mixed them up when typing. https://www.researchgate.net/figure/CD38-inhibition-by-quercetin-incr

Comment · Wed, October 7, 2020 · 1 pts

No problem! Sorry for the confusion.