Comment · Tue, September 29, 2020 · ND Owner
NMN, Niacin, NAD +, and Addiction
Original post in this thread
[deleted] · 5 points
I was really fascinated to see studies supporting the idea that NAD therapy could be a used pretty straightforwardly as a treatment for addiction:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278809/
It seems clear that NMN is one of the best oral routes to raise NAD levels, but there also seems to be evidence that straight niacin can raise NAD levels, at least in individuals considered deficient:
https://pubmed.ncbi.nlm.nih.gov/32386566/
The substance itself, and its systemic effects is quite exciting, but even more wild is that the founder of Alcoholics Anonymous, Bill W., was an extremely fervent (really almost religious) advocate of high doses of niacin for treating alcohol addiction. The fact that this seems to be supported, at least in theory, is pretty wild. I am always shocked when things that are viewed strictly as quackery (and I know there is indeed a lot of that) turn out to be validated. A bit like IV vitamin c being totally written off, and now being used in major hospitals to treat sepsis. Anyways, I wonder if anyone had any experiences, or thoughts to share on…
What they were answering
TheOptimizzzer · 1 points
Yeah I suppose even if true this would be more of an issue for elderly folks (who would theoretically have many more senescent cells) using it for the anti-aging purposes rather than someone younger using it for general performance/energy/quality of life.
And then I think the idea would be to use some form on senolytics (quecetin, egcg, pterostilbene, curcumin, etc) prior to the NMN to first decrease senescent cells. But I have no idea what the timing, protocol, etc would like like, just speculating.
u/MisterYouAreSoDumb · ND Owner
Yeah, it is definitely an interesting theory. I have been a bit more inflamed lately, but I have been moving houses and lifting a lot of stuff. So it is hard to say what is having the most effect there.