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Comment · Wed, July 22, 2020 · Natrium Health & Nootropics Depot

How safe is palmitoylethanolamide(PEA)?

Original post in this thread

JimmySteve3 · 8 points

I recently ordered some PEA and it just arrived in the mail today. I was doing a bit of extra research and came across a Reddit thread that had a user asking about whether there was any risk with PEA because it is a COX2 inhibitor. They were asking about whether it could cause a vascular event because of this. Is it safe for me to take PEA?

This is the link to the thread: https://amp.reddit.com/r/Nootropics/comments/6ayw8r/palmitoylethanolamide_pea_as_a_cox2_inhibitor/

What they were answering

Volcanyx · 1 points

Found this discussion when researching Oleoylethanolamide and was curious how it interacts with Palmitoylethanolamide. Is the other previously mentioned pairing product ,that was being developed, any closer to market?

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

Are you referring to oleamide, or actually oleoylethanolamide (OEA)? I have not personally tried OEA yet. I have some at our office, though. It's different than palmitoylethanolamide and oleamide in that it does not hit the endocannabinoid system like they do. It's a PPAR-α agonist. So it more signals the breakdown of lipids.

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