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Comment · Thu, October 24, 2019 · Natrium Health & Nootropics Depot

Is it true ND lion's mane is no good because it's not an alcohol extract?

Original post in this thread

PLAYING10 · 4 points

And it is optimized for beta-glucan. That beta-glucan has no effect on NGF or cognition.

Is this true? If it is what a shame bc I just started my ND LM like 10 days ago.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

There is a concerted effort by our competitors to discredit us in a number of ways right now. Don't fall for that shit. If you have any questions about things, ask me or my team. You can post on /r/NootropicsDepot and I can go into detail on your questions, my product specialist can jump in, or I can even get my lab director (who used to be a chemistry professor at Arizona State University) involved to answer things. The amount of knowledge we have on the ND team these days is second to none, and we could talk your ear off for hours on all sorts of things.

We sell two lion's mane versions. One is a water "extract" that is the exact same as the stuff used in the only two HUMAN clinical studies. That's our 1:1 product. The other is an alcohol extract of the same fruiting body mushrooms used in the 1:1 product. That one is our 8:1 product. Remember, the only human clinical research on lion's mane has used the equivalent of our 1:1 product. So any data you are seeing for mycelium or other extracts are either in vitro in a test tube, or in limited animal studies. Attempting to convince people that we should just ignore the human clinical research on lion's mane because of some test tube and animal studies is just stupid. Human clinical research is the pinnacle of what we should be looking for, as that is REAL WORLD data in humans. There is interesting data from the in vitro and animal studies, and some cool things can be done with that info. We are in the process of making a lion's mane product that will blow everyone else out of the water. However, there is real human clinical data on the 1:1 product. We should not discount that.

Furthermore, saying that beta-glucans have no effects on cognition is idiotic. They don't have the data to say that, one way or another. They are making huge leaps to conclusions based of limited data and a limited understanding of science. Frankly these people making the assertions you are referencing are desperately trying to grasp at anything they can to sell people overpriced products. Don't get me wrong, more potent extracts of things are cool. I love doing them! We ARE doing them. However, I am not going to discount human clinical research to try and sell them. On top of it all, there is a lack of scientific data on the analytical front. Standardizing to terpenes in lion's mane is fucking idiotic, and anyone doing it is an idiot. Period. Anyone claiming erinacine or hericenone concentrations is also a flat our liar. There are NO qualified reference standards for hericenones or erinacines yet. None. So we cannot quantify them yet. We are actually working on that, but it is a very difficult process that takes time. No way am I going to put a standardization on any of our products that is based in shitty science. That's not what we do. We are actually doing proper science the right way. When we release new things with numbers, those will be valid and based in sound science. Our competitors can make stupid standardizations and false data all they want. Go for it! It just shows people who is honest and who is trying anything they can to make money. Everyone here knows me. If I can bring out a novel high-potency thing, I will! We used to design our own completely new molecules at Ceretropic and bring them out. So innovating is not something I shy away from. So if you see me being cautious and slow on something, that's for a reason. The science has to be legitimate. It has to be real. Otherwise we are no better than the skeptics say we are: just making shit up and tricking people into buying something with fake data. That's not what we want in the nootropics community. We need to be better than that. When I am sure we are being better than that, we will release that product.

Again, the 1:1 and 8:1 extracts are GOOD products. The 1:1 is the closest to what was used in the human clinical research, and the 8:1 is a first attempt to make a more concentrated alcohol extract. We have much cooler ones on the way, but again the science needs to catch up. The products should follow the science, not the other way around.

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