Comment · Fri, October 25, 2019 · Natrium Health & Nootropics Depot

Is it true ND lion's mane is no good because it's not an alcohol extract?

Original post in this thread

PLAYING10 · 4 points

And it is optimized for beta-glucan. That beta-glucan has no effect on NGF or cognition.

Is this true? If it is what a shame bc I just started my ND LM like 10 days ago.

What they were answering

PLAYING10 · 1 points

Thanks. So does the 1:1 effect NGF? And now that I have you here... I had been feeling a bit light-headed since I started the LM. Today I didn't take it and I don't feel light-headed. Any idea why taking LM made me feel light-headed?

Edit: and if it does effect NGF does it effect it as much as the 8:1?

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

There are no human studies regarding lion's mane and NGF. So we cannot say for sure if any of them affect NGF in human brains. It's all speculation based off animal studies and ones dealing with mouse astroglial cells in vitro. Do we even want strong NGF effects in the brain? I am not sure, as there are no human studies on it yet. Maybe we do. However, we should avoid making strong statements one way or another till we have scientific data to back it up.

Many people do say that only erinacines have NGF effects, but a 1991 study showed hericenones did, too.

https://www.sciencedirect.com/science/article/pii/0040403991800399

The study most people reference for evidence that they don't is this one:

https://www.tandfonline.com/doi/full/10.1080/21501201003735556

Then you have this one that showed hericenones F, G and H stimulated NGF. Those are different than the usual hericenones people look at C, D and E.

https://www.sciencedirect.com/science/article/abs/pii/003194229280127Z

So the science is not settled, and we still do NOT have reference standards for any of these hericenones or erinacines. So it is very very hard to confirm any of these research paper's findings in the lab. Who knows, we might eventually find erinacines are in the fruiting bodies as well. It's either that, or the hericenones are affecting NGF, or the beneficial mechanism for cognition and mood is something other than NGF. The human clinical research used whole fruiting bodies. So there is something in there causing the benefits. Anyone saying we know for sure what those are and how they are working in the brain is not being scientifically honest.

As far as being light-headed, it is hard to say without wild speculation. It could be coincidence. It could be just your personal reaction to it. It's hard to say. Erinacine E is a kappa opioid agonist. So that might cause some effects like that. However, if you believe our competitors statements there are NO erinacines in our product. So that can't be it! LOL. I say that in jest. It could certainly be it, and everyone is wrong about the erinacine in fruiting bodies thing. Till I have reference standards I can't say for sure. I am working on it, though.

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