Comment · Mon, February 6, 2017 · Ceretropic & Nootropics Depot
Orexin-A and CNTF
Original post in this thread
Pereise1 · 12 points
So I've been trying out Ceretropic's Orexin-A for a week, still have about 3 weeks before I post a full review. As a person with Narcolepsy 2 however, this has been the single best substance I've ever tried, cutting my need for Amps/Armodafinil in half with better results. I had tried it for about 3 days when it barely arrived, however, I had a trip planned to the Dominican Republic so I left it at home, starting it up again just this week. I noticed that the great feeling I had during the first 3 days slowly starting waning by the end of my trip.
This leads me to a question: Can anybody (theoretically) think of a way to make this permanent? Would something that boosts CNTF help repopulate orexin neurons or orexin producing neurons in my hypothalamus?
Now, people who have Narcolepsy with Cataplexy, type 1, have an almost complete destruction of orexin in the hypothalamus. In the 2 autopsys done on people with Narcolepsy without Cataplexy, type 2, only a localized loss of orexin neurons was found:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717206/ - Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy
It also raises the question however, what's the fun…
What they were answering
Pereise1 · 2 points
So I'm still reading through the studies, gone through maybe half. My interest was piqued by the "Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system" study. They tracked orexin levels in different parts of the brain over the course of 120 minutes after administration. Is there any evidence that orexin-a administration would have an effect on orexin-producing neurons? Is there a peptide for that? (lol)
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Orexin-A directly binds to the orexin receptor. That study was showing that intranasal administration was effective at increasing brain levels of Orexin-A, which then can go on to activate orexin receptors.
This study goes into pretty good detail on the receptor bindings: http://pharmrev.aspetjournals.org/content/61/2/162