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Comment · Thu, April 28, 2016 · Ceretropic & Nootropics Depot

Kanna- fantastic anxiolytic nootropic

Original post in this thread

hungdaddy49 · 79 points

Recently got some Kanna (Sceletium Tortuosum) which is a south african plant with psychoactive properties. It apparently functions as an Serotonin release agent and an SRI

so far iv had great effects with the substance (300mg sublingual)

* Effects kick in after a few minutes

* Duration is seemingly much longer than tianeptine (8+ hours)

* There is no crash

* neuroprotective

* improves focus

* The anti-anxiety effect is stronger than tianeptine, compares to phenibut for me

* increases empathy, great for socialising

* Stimulating at first but then mellows out (great for relaxing sleep)

* The appetite suppressing effect is quite noticeable

i cant believe this stuff isnt more popular really. the feeling on it i would nearly describe as similar to low dose MDMA

*****EDIT****

Here is another review i found that was similar to my own experiences

http://www.bluelight.org/vb/threads/706718-Zembrin-Standard-Sceletium-Extract-50-mg-also-Phenibut-Aniracetam

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

I've been loving the kanna extract Zembrin the past few weeks. However, I use the recommended 25mg sublingually. 300mg is a bit high for an extract. It's not more popular here because people don't know about it. It's a relatively new compound to the US, and much more popular in South Africa.

Zembrin is an extract that focuses on getting the highest content of mesembrenone and mesembrine. Mesembrenone is a PDE-4 inhibitor (Ki of 470 nM). Mesembrine is the compound in it that acts as a serotonin re-uptake inhibitor (Ki of 1.4 nM). Pairing the SRI actions with the PDE-4 inhibition makes is not only effective as an anxiolytic and mood booster, but can improve cognition as well. It's pretty cool. I think it will become more popular as people hear about it.

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