Comment · Thu, September 10, 2015 · Ceretropic & Nootropics Depot

Amidate. What does it mean when a noot has amidate?

Original post in this thread

xelerated1 · 3 points

I saw the new epitalon amidate is out...but what does the 'amidate' actually do? As I read it, amidate is for "Inducing general anesthesia"

What they were answering

xelerated1 · 1 points

Thanks! Can you ELI5 the difference between the 3 Epitalon types? Rather, I know about the plain....but the other 2?

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

The regular has open N and C termini. The N-Acetyl has just an acetyl group on the N-terminus. The N-Acetyl Amidate has both an N-Acetyl group and a C-amide.

So think of the regular type as being the most susceptible to breakdown in the body. Enzymes can bind to and attack both ends easily. The N-Acetyl version only allows enzymes easy access to one end. The Amidate protects both ends. So each version just adds another layer of protection to the peptide, allowing it to stay in the body longer, and allowing more to pass the blood brain barrier.

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