Comment · Tue, September 8, 2015 · Ceretropic & Nootropics Depot
who sells r-phenylpiracetam
Original post in this thread
labratdream · 14 points
Do you know any vendors who sell r-phenylpiracetam ?
"The effect of (R)-phenylpiracetam is much stronger than that of methylphenidate and amphetamine. Moreover, (S)-phenylpiracetam produces only a very weak effect at 100 mg/kg, which is 2.5 times lower than (R)-phenylpiracetam, and no significant effect at 200 mg/kg."
"[0055] More detailed pharmacological data with (R)-phenylpiracetam have been published recently by the same authors (Zvejniece et al., Basic Clin Pharmacol Toxicol. 109, 407-12, 201 1 ). In the open-field test a significant increase in locomotor activity was found, which was just slightly stronger with the (R)-phenylpiracetam compared to (S)- phenylpiracetam. Also in the forced swim test, used as a model for depression, (R)- phenylpiracetam was also only slightly more potent than (S)-phenylpiracetam. However, in the passive avoidance test, (R)-phenylpiracetam enhanced memory function significantly better than (S)-phenylpiracetam. The authors conclude that these results may be important for the clinical use of optically pure isomers of phenylpiracetam"
What they were answering
FW900 · 9 points
With the RS-, you get 50% R-, making it pointless to pay for the optically pure R-.
You are also getting 50% S- which too crosses the BBB and has actions elsewhere that lessen R-phenlypiracetam's memory enhancing effects per the below study:
Investigation into stereoselective pharmacological activity of phenotropil (2011)
It's unfortunately not as simple as taking 2x the dose in order to equate a racemic mixture's effects to that of an optically pure compound. In fact, the results of the Passive Avoidance Response Test in the study (which is a rough gauge of rodent memory retention): increasing the dosage of racemic phenlypiracetam resulted in decreased cognition vs the lower dose whereas the r-isomer group saw an increase in memory retention, even more so with an increased dose. And the s-isomer in this test in the study arguably had anti-nootropic effects and caused a slight decrease in performance vs the saline group. With this in mind, it's far from pointless.
http://i.imgur.com/M9LyQtf.png
Possible explanations: There is one study that shows that racemic phenlypiracetam upregulates dopamine subreceptor density and another study shows that it demonstrates neuroleptic (antipsychotic) effects in rodents (will link later if anyone wants them). This is completely theoretical but I think it could be that s-phenlypiracetam ac…
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
I've been working on it too. The cost is a lot higher. However, that is not really an issue for me. I am willing to pay for it just to get it out there. The labs just keep dragging their feet on doing it. They like the simple synths that they can sell to lots of vendors. Getting a price from a lab is one thing. Getting them to actually go through with the synth is another. It's frustrating.