Comment · Sat, August 22, 2015 · Ceretropic
Four(-ish) questions about NA-Selank!
Original post in this thread
srubek · 10 points
ONE
It is widely accepted that NA-Selank's calming properties are attributable to its "induction of the metabolism of serotonin," right?
So my first real question is, what does that mean? Does it induce metabolism of serotonin into serotonin metabolites; or does it metabolize potential precursors into serotonin itself?
If the answer is the latter, then does this result in a net increase in serotonergic synaptic activity, or just an increase in synthesis & storage of it in the presynaptic vesicles?
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TWO
I'm also curious by what all mechanisms this is considered a nootropic...
So secondly, is its release of BDNF/NGF exclusive to the hippocampus?
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THREE
I've noticed that NA-Semax Amidate has an anxiolytic component to it; an effect that its non-amidated version is missing...and I would like to have that anxiolysis at night but without Semax's stimulation...hence my third big question:
Would it potentially be more effective, anxiolytic, and/or longer lasting with an 'amidated' C-terminus or other...terminus? (please forgive and correct my technical errors--I prefer precision, and…
What they were answering
Debonaire_Death · 2 points
I certainly get none of the negative effects from NASEMAXA that I do from SEMAX, suggesting some sort of difference systemically.
Have they confirmed that amidating the molecule changes how it binds to copper? I also can't help but wonder if we are getting amidated/acetylated metabolites from such modifications, as well, further complicating how the MOA is changed.
u/MisterYouAreSoDumb · Ceretropic
There is no official confirmation that the amidation alters the copper binding. However, I am pretty damn sure it does.