Comment · Fri, August 21, 2015 · Ceretropic
Four(-ish) questions about NA-Selank!
Original post in this thread
srubek · 10 points
ONE
It is widely accepted that NA-Selank's calming properties are attributable to its "induction of the metabolism of serotonin," right?
So my first real question is, what does that mean? Does it induce metabolism of serotonin into serotonin metabolites; or does it metabolize potential precursors into serotonin itself?
If the answer is the latter, then does this result in a net increase in serotonergic synaptic activity, or just an increase in synthesis & storage of it in the presynaptic vesicles?
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TWO
I'm also curious by what all mechanisms this is considered a nootropic...
So secondly, is its release of BDNF/NGF exclusive to the hippocampus?
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THREE
I've noticed that NA-Semax Amidate has an anxiolytic component to it; an effect that its non-amidated version is missing...and I would like to have that anxiolysis at night but without Semax's stimulation...hence my third big question:
Would it potentially be more effective, anxiolytic, and/or longer lasting with an 'amidated' C-terminus or other...terminus? (please forgive and correct my technical errors--I prefer precision, and…
What they were answering
srubek · 2 points
Thanks, Paul. I was sorta hoping someone else could have enlightened me, instead of always having it fall on you. So...thanks again for taking the time & thought.
Until we do some animal studies, we are going to have to speculate about the specifics, though.
I'm still all ears for speculation!
u/MisterYouAreSoDumb · Ceretropic
Well my speculation is the acetylation and amidation is increasing blood brain barrier permeability, protecting it from enzymatic degradation, and leading to more of each peptide sub-sequence in parts of the brain. The charge of the sequences might be altering the binding affinities as well.